FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058566642> ?p ?o ?g. }

• W2058566642 endingPage "2305" @default.
• W2058566642 startingPage "2293" @default.
• W2058566642 abstract "After traumatic brain injury (TBI), inflammation participates in both the secondary injury cascades and the repair of the CNS, both of which are influenced by the endocannabinoid system. This study determined the effects of repeated treatment with a cannabinoid type 2 receptor (CB2R) agonist on blood–brain barrier integrity, neuronal degeneration, and behavioral outcome in mice with TBI. We also looked for the presence of a prolonged treatment effect on the macrophage/microglial response to injury. C57BL/6 mice underwent controlled cortical impact (CCI) and received repeated treatments with a CB2R agonist, 0-1966, or vehicle. After euthanasia at 6 hr or 1, 2, 3, or 7 days postinjury, brains were removed for histochemical analysis. Blood–brain barrier permeability changes were evaluated by using sodium fluorescein (NaF). Perilesional degenerating neurons, injury volumes, and macrophage/microglia cells were quantified by stereological methods. Rota-rod and open-field testing were performed to evaluate motor function and natural exploratory behavior in mice. 0-1966 Treatment resulted in a significant reduction in NaF uptake and number of degenerating neurons compared with the vehicle-treated group. 0-1966-Treated mice demonstrated improvement on rota-rod and open-field testing compared with vehicle-treated mice. These changes in CCI mice treated with 0-1966 were associated with a prolonged reduction in macrophage/microglia cell counts. In conclusion, repeated treatments with a CB2R agonist, 0-1966, result in attenuated blood–brain barrier disruption and neuronal degeneration. In addition, repeated treatment with 0-1966 shows prolonged treatment effects on behavior and the macrophage/microglia cell response over several days. © 2012 Wiley Periodicals, Inc." @default.
• W2058566642 created "2016-06-24" @default.
• W2058566642 creator A5016575156 @default.
• W2058566642 creator A5057087677 @default.
• W2058566642 creator A5076081812 @default.
• W2058566642 creator A5088592845 @default.
• W2058566642 date "2012-08-18" @default.
• W2058566642 modified "2023-09-25" @default.
• W2058566642 title "A cannabinoid type 2 receptor agonist attenuates blood-brain barrier damage and neurodegeneration in a murine model of traumatic brain injury" @default.
• W2058566642 cites W1492320195 @default.
• W2058566642 cites W1500452901 @default.
• W2058566642 cites W1541402103 @default.
• W2058566642 cites W1542528083 @default.
• W2058566642 cites W1824285398 @default.
• W2058566642 cites W1896273345 @default.
• W2058566642 cites W1928931031 @default.
• W2058566642 cites W1956139961 @default.
• W2058566642 cites W1964041350 @default.
• W2058566642 cites W1964395752 @default.
• W2058566642 cites W1972820094 @default.
• W2058566642 cites W1973719910 @default.
• W2058566642 cites W1973831188 @default.
• W2058566642 cites W1974626393 @default.
• W2058566642 cites W1976002291 @default.
• W2058566642 cites W1982229018 @default.
• W2058566642 cites W1984059880 @default.
• W2058566642 cites W1984854284 @default.
• W2058566642 cites W1990514899 @default.
• W2058566642 cites W1991497324 @default.
• W2058566642 cites W1992617791 @default.
• W2058566642 cites W1993054804 @default.
• W2058566642 cites W1993220836 @default.
• W2058566642 cites W2002669868 @default.
• W2058566642 cites W2002785222 @default.
• W2058566642 cites W2003758042 @default.
• W2058566642 cites W2015943785 @default.
• W2058566642 cites W2016495821 @default.
• W2058566642 cites W2021968670 @default.
• W2058566642 cites W2023366312 @default.
• W2058566642 cites W2024201248 @default.
• W2058566642 cites W2026079336 @default.
• W2058566642 cites W2026985565 @default.
• W2058566642 cites W2028312992 @default.
• W2058566642 cites W2028794471 @default.
• W2058566642 cites W2032715817 @default.
• W2058566642 cites W2034607987 @default.
• W2058566642 cites W2042822864 @default.
• W2058566642 cites W2046392540 @default.
• W2058566642 cites W2048283239 @default.
• W2058566642 cites W2052473808 @default.
• W2058566642 cites W2053176712 @default.
• W2058566642 cites W2053336013 @default.
• W2058566642 cites W2055309785 @default.
• W2058566642 cites W2056188558 @default.
• W2058566642 cites W2057976080 @default.
• W2058566642 cites W2058035812 @default.
• W2058566642 cites W2058955046 @default.
• W2058566642 cites W2061476401 @default.
• W2058566642 cites W2063065406 @default.
• W2058566642 cites W2065034252 @default.
• W2058566642 cites W2066681847 @default.
• W2058566642 cites W2067487401 @default.
• W2058566642 cites W2073856575 @default.
• W2058566642 cites W2074510736 @default.
• W2058566642 cites W2075171154 @default.
• W2058566642 cites W2076807570 @default.
• W2058566642 cites W2079729010 @default.
• W2058566642 cites W2081957132 @default.
• W2058566642 cites W2084121027 @default.
• W2058566642 cites W2089531530 @default.
• W2058566642 cites W2100339643 @default.
• W2058566642 cites W2109194131 @default.
• W2058566642 cites W2109698334 @default.
• W2058566642 cites W2109759840 @default.
• W2058566642 cites W2111152176 @default.
• W2058566642 cites W2119826244 @default.
• W2058566642 cites W2119958966 @default.
• W2058566642 cites W2124248227 @default.
• W2058566642 cites W2135446008 @default.
• W2058566642 cites W2145798230 @default.
• W2058566642 cites W2146663965 @default.
• W2058566642 cites W2148637213 @default.
• W2058566642 cites W2163150813 @default.
• W2058566642 cites W2164485911 @default.
• W2058566642 cites W2169052846 @default.
• W2058566642 cites W4255175571 @default.
• W2058566642 cites W1968641130 @default.
• W2058566642 doi "https://doi.org/10.1002/jnr.23114" @default.
• W2058566642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22903455" @default.
• W2058566642 hasPublicationYear "2012" @default.
• W2058566642 type Work @default.
• W2058566642 sameAs 2058566642 @default.
• W2058566642 citedByCount "88" @default.
• W2058566642 countsByYear W20585666422013 @default.
• W2058566642 countsByYear W20585666422014 @default.
• W2058566642 countsByYear W20585666422015 @default.
• W2058566642 countsByYear W20585666422016 @default.
• W2058566642 countsByYear W20585666422017 @default.

• next