FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058567949> ?p ?o ?g. }

• W2058567949 endingPage "5748" @default.
• W2058567949 startingPage "5738" @default.
• W2058567949 abstract "The δ2 glutamate receptor (GluRδ2; GluD2), which is predominantly expressed on postsynaptic sites at parallel fiber (PF)–Purkinje cell synapses in the cerebellum, plays two crucial roles in the cerebellum: the formation of PF synapses and the regulation of long-term depression (LTD), a form of synaptic plasticity underlying motor learning. Although the induction of LTD and motor learning absolutely require signaling via the cytoplasmic C-terminal domain of GluD2, the mechanisms by which GluD2 regulates PF synaptogenesis have remained unclear. Here, we examined the role of the extracellular N-terminal domain (NTD) of GluD2 on PF synaptogenesis by injecting Sindbis virus carrying wild-type (GluD2 wt ) or mutant GluD2 into the subarachnoid supracerebellar space of GluD2 -null mice. Remarkably, the expression of GluD2 wt , but not of a mutant GluD2 lacking the NTD (GluD2 ΔNTD ), rapidly induced PF synapse formation and rescued gross motor dyscoordination in adult GluD2 -null mice just 1 d after injection. In addition, although the kainate receptor GluR6 (GluK2) did not induce PF synaptogenesis, a chimeric GluK2 that contained the NTD of GluD2 (GluD2 NTD –GluK2) did. Similarly, GluD2 wt and GluD2 NTD –GluK2, but not GluD2 ΔNTD , induced synaptogenesis in heterologous cells in vitro . In contrast, LTD was restored in GluD2 -null Purkinje cells expressing a mutant GluD2 lacking the NTD. These results indicate that the NTD of GluD2 is necessary and sufficient for the function of GluD2 in the regulation of PF–Purkinje cell synaptogenesis. Furthermore, our results suggest that GluD2 differently regulates PF synaptogenesis and cerebellar LTD through the extracellular NTD and the cytoplasmic C-terminal end, respectively." @default.
• W2058567949 created "2016-06-24" @default.
• W2058567949 creator A5004735508 @default.
• W2058567949 creator A5015389182 @default.
• W2058567949 creator A5017811687 @default.
• W2058567949 creator A5021704016 @default.
• W2058567949 creator A5025215807 @default.
• W2058567949 creator A5037576209 @default.
• W2058567949 creator A5063425312 @default.
• W2058567949 creator A5077366980 @default.
• W2058567949 date "2009-05-06" @default.
• W2058567949 modified "2023-10-02" @default.
• W2058567949 title "The N-Terminal Domain of GluD2 (GluRδ2) Recruits Presynaptic Terminals and Regulates Synaptogenesis in the Cerebellum<i>In Vivo</i>" @default.
• W2058567949 cites W1498735063 @default.
• W2058567949 cites W1503086218 @default.
• W2058567949 cites W1520699767 @default.
• W2058567949 cites W1545709084 @default.
• W2058567949 cites W1593745576 @default.
• W2058567949 cites W1594006457 @default.
• W2058567949 cites W1647174225 @default.
• W2058567949 cites W1765307519 @default.
• W2058567949 cites W1855713874 @default.
• W2058567949 cites W1931451724 @default.
• W2058567949 cites W1948270772 @default.
• W2058567949 cites W1963733435 @default.
• W2058567949 cites W1967209558 @default.
• W2058567949 cites W1969903489 @default.
• W2058567949 cites W1979996083 @default.
• W2058567949 cites W1980261326 @default.
• W2058567949 cites W1984702583 @default.
• W2058567949 cites W1984996211 @default.
• W2058567949 cites W1988012148 @default.
• W2058567949 cites W1992084662 @default.
• W2058567949 cites W1992187858 @default.
• W2058567949 cites W1996314349 @default.
• W2058567949 cites W1997032972 @default.
• W2058567949 cites W2005793571 @default.
• W2058567949 cites W2007495877 @default.
• W2058567949 cites W2008113638 @default.
• W2058567949 cites W2008564986 @default.
• W2058567949 cites W2021126503 @default.
• W2058567949 cites W2021429993 @default.
• W2058567949 cites W2024446183 @default.
• W2058567949 cites W2026501792 @default.
• W2058567949 cites W2029868316 @default.
• W2058567949 cites W2032447644 @default.
• W2058567949 cites W2039446946 @default.
• W2058567949 cites W2041183345 @default.
• W2058567949 cites W2041249898 @default.
• W2058567949 cites W2046165746 @default.
• W2058567949 cites W2051434331 @default.
• W2058567949 cites W2055522277 @default.
• W2058567949 cites W2064229854 @default.
• W2058567949 cites W2068093158 @default.
• W2058567949 cites W2069221168 @default.
• W2058567949 cites W2070501686 @default.
• W2058567949 cites W2077211332 @default.
• W2058567949 cites W2083703255 @default.
• W2058567949 cites W2086410429 @default.
• W2058567949 cites W2086411257 @default.
• W2058567949 cites W2088067485 @default.
• W2058567949 cites W2092326283 @default.
• W2058567949 cites W2103731399 @default.
• W2058567949 cites W2104376441 @default.
• W2058567949 cites W2107339318 @default.
• W2058567949 cites W2114911122 @default.
• W2058567949 cites W2115027435 @default.
• W2058567949 cites W2120598509 @default.
• W2058567949 cites W2121405440 @default.
• W2058567949 cites W2125287331 @default.
• W2058567949 cites W2143968827 @default.
• W2058567949 cites W2148673800 @default.
• W2058567949 cites W2151251384 @default.
• W2058567949 cites W2160663696 @default.
• W2058567949 cites W2162281220 @default.
• W2058567949 cites W2164282258 @default.
• W2058567949 cites W4293416615 @default.
• W2058567949 cites W4320995227 @default.
• W2058567949 doi "https://doi.org/10.1523/jneurosci.6013-08.2009" @default.
• W2058567949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6665243" @default.
• W2058567949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19420242" @default.
• W2058567949 hasPublicationYear "2009" @default.
• W2058567949 type Work @default.
• W2058567949 sameAs 2058567949 @default.
• W2058567949 citedByCount "62" @default.
• W2058567949 countsByYear W20585679492012 @default.
• W2058567949 countsByYear W20585679492013 @default.
• W2058567949 countsByYear W20585679492014 @default.
• W2058567949 countsByYear W20585679492016 @default.
• W2058567949 countsByYear W20585679492017 @default.
• W2058567949 countsByYear W20585679492018 @default.
• W2058567949 countsByYear W20585679492019 @default.
• W2058567949 countsByYear W20585679492020 @default.
• W2058567949 countsByYear W20585679492021 @default.
• W2058567949 countsByYear W20585679492023 @default.
• W2058567949 crossrefType "journal-article" @default.
• W2058567949 hasAuthorship W2058567949A5004735508 @default.
• W2058567949 hasAuthorship W2058567949A5015389182 @default.

• next