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- W2058580623 abstract "To investigate the effects of obesity and exercise training on regional adipose tissue angiogenesis and hypoxia markers in rats.Lean (Fa/Fa) and obese (fa/fa) male Zucker rats at 2 months of age were randomly assigned to a sedentary or an exercise training group (lean sedentary: n=7, lean exercise: n=8, obese sedentary: n=7, obese exercise: n=8). The exercise group walked on a rat treadmill 5 times per week for 8 weeks. Inguinal and epididymal adipose tissue vascular endothelial growth factor A (VEGF-A) and lactate levels were determined.There were significant effects of obesity in increasing inguinal (P<0.001) and epididymal (P<0.05) adipose tissue VEGF-A, and a significant effect of exercise training in increasing epididymal adipose tissue VEGF-A (P<0.05). There was a significant effect of obesity in increasing inguinal adipose tissue lactate levels (P<0.001). Compared to lean sedentary animals, obese sedentary animals had significantly higher epididymal adipose tissue lactate levels (P<0.001); compared to obese sedentary animals, obese exercise rats had significantly lower epididymal adipose tissue lactate levels (P<0.05).Exercise training increased adipose tissue VEGF-A, an important factor of tissue angiogenesis, and lowered adipose tissue lactate, an indicator of adipose tissue hypoxia in obese rats. However, these effects are depot-specific and only observed in intra-abdominal adipose tissue." @default.
- W2058580623 created "2016-06-24" @default.
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- W2058580623 date "2014-04-01" @default.
- W2058580623 modified "2023-10-01" @default.
- W2058580623 title "Effects of exercise training on indicators of adipose tissue angiogenesis and hypoxia in obese rats" @default.
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- W2058580623 doi "https://doi.org/10.1016/j.metabol.2013.12.004" @default.
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