Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058590950> ?p ?o ?g. }
- W2058590950 endingPage "277" @default.
- W2058590950 startingPage "270" @default.
- W2058590950 abstract "Cellular senescence is a biologically irreversible state of cell-growth arrest that occurs following either a replicative or an oncogenic stimulus. This phenomenon occurs as a response to the presence of premalignant cells and appears to be an important anticancer mechanism that keeps these transformed cells at bay. Many exogenous and endogenous triggers for senescence have been recognized to act via genomic or epigenomic pathways. The most common stimulus for senescence is progressive loss of telomeric DNA, which results in the loss of chromosomal stability and eventual unregulated growth and malignancy. Senescence is activated through an interaction between the p16 and p53 tumor-suppressor genes. Senescent cells can be identified in vitro because they express senescence-associated β-galactosidase, a marker of increased lysosomal activity. Cellular senescence plays an integral role in the prevention and development of both benign and malignant gastrointestinal diseases. The senescence cascade and the cell-cycle checkpoints that dictate the progression and maintenance of senescence are important in all types of gastrointestinal cancers, including pancreatic, liver, gastric, colon, and esophageal cancers. Understanding the pathogenic mechanisms involved in cellular senescence is important for the development of agents targeted toward the treatment of gastrointestinal tumors." @default.
- W2058590950 created "2016-06-24" @default.
- W2058590950 creator A5002493916 @default.
- W2058590950 creator A5036826569 @default.
- W2058590950 creator A5060812584 @default.
- W2058590950 creator A5069703154 @default.
- W2058590950 date "2013-05-15" @default.
- W2058590950 modified "2023-10-18" @default.
- W2058590950 title "The Role of Cellular Senescence in the Gastrointestinal Mucosa" @default.
- W2058590950 cites W1513066662 @default.
- W2058590950 cites W151650441 @default.
- W2058590950 cites W1533710382 @default.
- W2058590950 cites W1558165792 @default.
- W2058590950 cites W1594652218 @default.
- W2058590950 cites W168179040 @default.
- W2058590950 cites W1967530830 @default.
- W2058590950 cites W1970924670 @default.
- W2058590950 cites W1973147485 @default.
- W2058590950 cites W1978744384 @default.
- W2058590950 cites W1980560452 @default.
- W2058590950 cites W1982395176 @default.
- W2058590950 cites W1996113298 @default.
- W2058590950 cites W2004273407 @default.
- W2058590950 cites W2010099039 @default.
- W2058590950 cites W2010345740 @default.
- W2058590950 cites W2015141512 @default.
- W2058590950 cites W2015665286 @default.
- W2058590950 cites W2017906301 @default.
- W2058590950 cites W2027082499 @default.
- W2058590950 cites W2028169108 @default.
- W2058590950 cites W2030379493 @default.
- W2058590950 cites W2030795773 @default.
- W2058590950 cites W2038255016 @default.
- W2058590950 cites W2038464222 @default.
- W2058590950 cites W2044387885 @default.
- W2058590950 cites W2047330128 @default.
- W2058590950 cites W2050852029 @default.
- W2058590950 cites W2051219434 @default.
- W2058590950 cites W2060648544 @default.
- W2058590950 cites W2061111966 @default.
- W2058590950 cites W2071825552 @default.
- W2058590950 cites W2074198797 @default.
- W2058590950 cites W2083301581 @default.
- W2058590950 cites W2086023583 @default.
- W2058590950 cites W2101007892 @default.
- W2058590950 cites W2108273756 @default.
- W2058590950 cites W2117674153 @default.
- W2058590950 cites W2122281119 @default.
- W2058590950 cites W2124218395 @default.
- W2058590950 cites W2132224453 @default.
- W2058590950 cites W2135564059 @default.
- W2058590950 cites W2138631175 @default.
- W2058590950 cites W2140288034 @default.
- W2058590950 cites W2144154026 @default.
- W2058590950 cites W2147030667 @default.
- W2058590950 cites W2151175247 @default.
- W2058590950 cites W2152662800 @default.
- W2058590950 cites W2154799239 @default.
- W2058590950 cites W2161080185 @default.
- W2058590950 cites W2166704790 @default.
- W2058590950 cites W2167040496 @default.
- W2058590950 cites W4236069703 @default.
- W2058590950 cites W4246602266 @default.
- W2058590950 doi "https://doi.org/10.5009/gnl.2013.7.3.270" @default.
- W2058590950 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3661957" @default.
- W2058590950 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23710306" @default.
- W2058590950 hasPublicationYear "2013" @default.
- W2058590950 type Work @default.
- W2058590950 sameAs 2058590950 @default.
- W2058590950 citedByCount "14" @default.
- W2058590950 countsByYear W20585909502014 @default.
- W2058590950 countsByYear W20585909502015 @default.
- W2058590950 countsByYear W20585909502018 @default.
- W2058590950 countsByYear W20585909502020 @default.
- W2058590950 countsByYear W20585909502021 @default.
- W2058590950 countsByYear W20585909502022 @default.
- W2058590950 countsByYear W20585909502023 @default.
- W2058590950 crossrefType "journal-article" @default.
- W2058590950 hasAuthorship W2058590950A5002493916 @default.
- W2058590950 hasAuthorship W2058590950A5036826569 @default.
- W2058590950 hasAuthorship W2058590950A5060812584 @default.
- W2058590950 hasAuthorship W2058590950A5069703154 @default.
- W2058590950 hasBestOaLocation W20585909502 @default.
- W2058590950 hasConcept C104317684 @default.
- W2058590950 hasConcept C105696609 @default.
- W2058590950 hasConcept C127716648 @default.
- W2058590950 hasConcept C143425029 @default.
- W2058590950 hasConcept C1491633281 @default.
- W2058590950 hasConcept C177336024 @default.
- W2058590950 hasConcept C178169997 @default.
- W2058590950 hasConcept C2779523775 @default.
- W2058590950 hasConcept C29537977 @default.
- W2058590950 hasConcept C502942594 @default.
- W2058590950 hasConcept C522857546 @default.
- W2058590950 hasConcept C54355233 @default.
- W2058590950 hasConcept C552990157 @default.
- W2058590950 hasConcept C62112901 @default.
- W2058590950 hasConcept C71924100 @default.