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- W2058590957 abstract "The detection of carcinogenic chemicals still remains a major challenge. The only carcinogenicity test accepted by regulatory authorities is the in vivo two-year bioassay. In the area of genotoxicity, although several in vitro assays are currently used, substantial in vivo testing is still required for confirmation of the genotoxic prediction. To face these challenges, the ECVAM key area on carcinogenicity and genotoxicity was established in January 2004 with the initiation of several activities related both to validation and applied research. • Ongoing validation Cell Transformation Assay in BALB/c 3T3 and SHE cells to detect genotoxic and non-genotoxic carcinogens (first international validation study involving Europe, USA and Japan). • Retrospective validation on in vitro Micronucleus Test based on the existing data and the ECVAM criteria for validation. ESAC statement on the validity of the MNT in vitro as an alternative to chromosome aberration test in vitro for genotoxicity testing was issued November 2006 (follow-up validation in vitro/in vivo MNT). • A submission of an in silico tool to predict rodent carcinogenicity is under evaluation. • Current data collection from industry to investigate reduction possibilities, e.g. omission of positive/negative controls in in vivo genotoxicity testing, reduction of the false positive in vitro results that lead to further in vivo testing (follow-up on ECVAM workshop recommendations in collaboration with COLIPA) • Inter-laboratory assessment of genotoxicity tests in target cells. • COMET assay in 3D skin model (in collaboration with COLIPA). • Toxicogenomics-based tests, e.g. exploratory project to search for biomarkers of exposure in BALB/c 3T3. ECVAM is involved also in support to OECD activities (DRP31 and TG development), REACH Implementation Project RIP 3.3.2, the validation of COMET assay coordinated by JaCVAM and the EU Competitive actions: CARCINOGENOMICS and COMICS." @default.
- W2058590957 created "2016-06-24" @default.
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- W2058590957 date "2009-05-01" @default.
- W2058590957 modified "2023-09-25" @default.
- W2058590957 title "S19: Alternative in vitro methods for carcinogenicity and mutagenicity" @default.
- W2058590957 doi "https://doi.org/10.1016/j.etp.2009.02.020" @default.
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