Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058596770> ?p ?o ?g. }
- W2058596770 endingPage "98" @default.
- W2058596770 startingPage "93" @default.
- W2058596770 abstract "Tumour necrosis factor (TNF)‐related apoptosis‐inducing ligand (TRAIL) is a member of the TNF family of cytokines that promotes apoptosis and NF‐κB activation. Here we show that recombinant hu‐TRAIL initiates the activation of multiple caspases, the loss of mitochondrial transmembrane potential, the cleavage of BID and the redistribution of mitochondrial cytochrome c . However, whereas Bcl‐2 efficiently blocked UV radiation‐induced cytochrome c release and consequent apoptosis of CEM cells, it failed to do either in the context of TRAIL treatment. Thus, TRAIL engages a death pathway that is at least partially routed via the mitochondria, but in contrast with other stimuli that engage this pathway, TRAIL‐induced cytochrome c release is not regulated by Bcl‐2." @default.
- W2058596770 created "2016-06-24" @default.
- W2058596770 creator A5040708190 @default.
- W2058596770 creator A5058432557 @default.
- W2058596770 creator A5085552716 @default.
- W2058596770 creator A5088615764 @default.
- W2058596770 date "2000-04-05" @default.
- W2058596770 modified "2023-10-17" @default.
- W2058596770 title "Failure of Bcl‐2 to block cytochrome <i>c</i> redistribution during TRAIL‐induced apoptosis" @default.
- W2058596770 cites W1484817497 @default.
- W2058596770 cites W1507810589 @default.
- W2058596770 cites W1521538212 @default.
- W2058596770 cites W1567258255 @default.
- W2058596770 cites W1644794975 @default.
- W2058596770 cites W1644953918 @default.
- W2058596770 cites W1962843014 @default.
- W2058596770 cites W1968527208 @default.
- W2058596770 cites W1973109581 @default.
- W2058596770 cites W1976226379 @default.
- W2058596770 cites W1978857213 @default.
- W2058596770 cites W1979995768 @default.
- W2058596770 cites W1980919524 @default.
- W2058596770 cites W1982661150 @default.
- W2058596770 cites W1984709119 @default.
- W2058596770 cites W1988043250 @default.
- W2058596770 cites W1995638825 @default.
- W2058596770 cites W2012173926 @default.
- W2058596770 cites W2017578232 @default.
- W2058596770 cites W2030892254 @default.
- W2058596770 cites W2032417513 @default.
- W2058596770 cites W2056217426 @default.
- W2058596770 cites W2062853648 @default.
- W2058596770 cites W2075477970 @default.
- W2058596770 cites W2076807689 @default.
- W2058596770 cites W2087450028 @default.
- W2058596770 cites W2089476060 @default.
- W2058596770 cites W2092196409 @default.
- W2058596770 cites W2092508425 @default.
- W2058596770 cites W2094334993 @default.
- W2058596770 cites W2098439946 @default.
- W2058596770 cites W2104713798 @default.
- W2058596770 cites W2105186639 @default.
- W2058596770 cites W2108131089 @default.
- W2058596770 cites W2113505777 @default.
- W2058596770 cites W2113999599 @default.
- W2058596770 cites W2119683782 @default.
- W2058596770 cites W2122482353 @default.
- W2058596770 cites W2124598613 @default.
- W2058596770 cites W2130866079 @default.
- W2058596770 cites W2130988210 @default.
- W2058596770 cites W2144701362 @default.
- W2058596770 cites W2157999078 @default.
- W2058596770 cites W2159650080 @default.
- W2058596770 cites W2166291746 @default.
- W2058596770 cites W2315994643 @default.
- W2058596770 cites W2505644460 @default.
- W2058596770 cites W4313379464 @default.
- W2058596770 doi "https://doi.org/10.1016/s0014-5793(00)01375-2" @default.
- W2058596770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10760520" @default.
- W2058596770 hasPublicationYear "2000" @default.
- W2058596770 type Work @default.
- W2058596770 sameAs 2058596770 @default.
- W2058596770 citedByCount "106" @default.
- W2058596770 countsByYear W20585967702012 @default.
- W2058596770 countsByYear W20585967702016 @default.
- W2058596770 countsByYear W20585967702018 @default.
- W2058596770 countsByYear W20585967702019 @default.
- W2058596770 crossrefType "journal-article" @default.
- W2058596770 hasAuthorship W2058596770A5040708190 @default.
- W2058596770 hasAuthorship W2058596770A5058432557 @default.
- W2058596770 hasAuthorship W2058596770A5085552716 @default.
- W2058596770 hasAuthorship W2058596770A5088615764 @default.
- W2058596770 hasBestOaLocation W20585967702 @default.
- W2058596770 hasConcept C163421366 @default.
- W2058596770 hasConcept C173358068 @default.
- W2058596770 hasConcept C17991360 @default.
- W2058596770 hasConcept C185592680 @default.
- W2058596770 hasConcept C190283241 @default.
- W2058596770 hasConcept C193349765 @default.
- W2058596770 hasConcept C203014093 @default.
- W2058596770 hasConcept C28859421 @default.
- W2058596770 hasConcept C29311851 @default.
- W2058596770 hasConcept C31573885 @default.
- W2058596770 hasConcept C55493867 @default.
- W2058596770 hasConcept C86803240 @default.
- W2058596770 hasConcept C95444343 @default.
- W2058596770 hasConcept C98424977 @default.
- W2058596770 hasConceptScore W2058596770C163421366 @default.
- W2058596770 hasConceptScore W2058596770C173358068 @default.
- W2058596770 hasConceptScore W2058596770C17991360 @default.
- W2058596770 hasConceptScore W2058596770C185592680 @default.
- W2058596770 hasConceptScore W2058596770C190283241 @default.
- W2058596770 hasConceptScore W2058596770C193349765 @default.
- W2058596770 hasConceptScore W2058596770C203014093 @default.
- W2058596770 hasConceptScore W2058596770C28859421 @default.
- W2058596770 hasConceptScore W2058596770C29311851 @default.
- W2058596770 hasConceptScore W2058596770C31573885 @default.
- W2058596770 hasConceptScore W2058596770C55493867 @default.