Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058598294> ?p ?o ?g. }
- W2058598294 endingPage "41" @default.
- W2058598294 startingPage "31" @default.
- W2058598294 abstract "Liposomally formulated siRNA can be used for RNAi applications in vivo. Intravenous bolus administration of lipoplexed siRNA has been shown to reduce gene expression in the vascular endothelium. Here, we applied immunofluorescence staining for different endothelial markers (PECAM-1, CD34, laminin) on paraffin sections to compare the respective expression pattern with the intracellular localization of intravenously administered, fluorescently labeled siRNA (siRNA-Cy3-lipoplex). By confocal microscopy, lipoplexed siRNA-Cy3 was detected inside vascular endothelial cells in vivo, which where identified with co-staining of endothelial markers. Consequently, the finding of intracellular siRNA uptake by vascular endothelial cells correlated with RNAi based specific protein reduction in situ as revealed by PECAM-1 specific immunofluorescence staining in lung tissue sections. Therefore, by using a cell biological approach these in situ data emphasize the functional uptake of liposomal siRNA molecules in vascular endothelial cells of different mouse tissues as indicated in our previous molecular study." @default.
- W2058598294 created "2016-06-24" @default.
- W2058598294 creator A5025325301 @default.
- W2058598294 creator A5028553670 @default.
- W2058598294 creator A5031092625 @default.
- W2058598294 creator A5053145696 @default.
- W2058598294 creator A5066283050 @default.
- W2058598294 creator A5082712473 @default.
- W2058598294 creator A5087047675 @default.
- W2058598294 date "2008-05-01" @default.
- W2058598294 modified "2023-09-27" @default.
- W2058598294 title "Intracellular localization of lipoplexed siRNA in vascular endothelial cells of different mouse tissues" @default.
- W2058598294 cites W1611419331 @default.
- W2058598294 cites W1647075334 @default.
- W2058598294 cites W1967323327 @default.
- W2058598294 cites W1968968207 @default.
- W2058598294 cites W1974158357 @default.
- W2058598294 cites W1975604213 @default.
- W2058598294 cites W1984085632 @default.
- W2058598294 cites W2000984699 @default.
- W2058598294 cites W2001583023 @default.
- W2058598294 cites W2021233808 @default.
- W2058598294 cites W2026950582 @default.
- W2058598294 cites W2027375557 @default.
- W2058598294 cites W2041141014 @default.
- W2058598294 cites W2045359762 @default.
- W2058598294 cites W2084147384 @default.
- W2058598294 cites W2086333325 @default.
- W2058598294 cites W2091574626 @default.
- W2058598294 cites W2102015925 @default.
- W2058598294 cites W2111605241 @default.
- W2058598294 cites W2117117603 @default.
- W2058598294 cites W2119303378 @default.
- W2058598294 cites W2122935177 @default.
- W2058598294 cites W2129081579 @default.
- W2058598294 cites W2129752592 @default.
- W2058598294 cites W2134467061 @default.
- W2058598294 cites W2141547126 @default.
- W2058598294 cites W2145638174 @default.
- W2058598294 cites W2152029916 @default.
- W2058598294 cites W2155783433 @default.
- W2058598294 cites W2157225099 @default.
- W2058598294 cites W2172210768 @default.
- W2058598294 cites W2332930343 @default.
- W2058598294 cites W4205948329 @default.
- W2058598294 cites W4378836288 @default.
- W2058598294 cites W274441265 @default.
- W2058598294 doi "https://doi.org/10.1016/j.mvr.2008.02.004" @default.
- W2058598294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18455200" @default.
- W2058598294 hasPublicationYear "2008" @default.
- W2058598294 type Work @default.
- W2058598294 sameAs 2058598294 @default.
- W2058598294 citedByCount "24" @default.
- W2058598294 countsByYear W20585982942012 @default.
- W2058598294 countsByYear W20585982942013 @default.
- W2058598294 countsByYear W20585982942014 @default.
- W2058598294 countsByYear W20585982942016 @default.
- W2058598294 countsByYear W20585982942017 @default.
- W2058598294 countsByYear W20585982942019 @default.
- W2058598294 countsByYear W20585982942021 @default.
- W2058598294 countsByYear W20585982942022 @default.
- W2058598294 crossrefType "journal-article" @default.
- W2058598294 hasAuthorship W2058598294A5025325301 @default.
- W2058598294 hasAuthorship W2058598294A5028553670 @default.
- W2058598294 hasAuthorship W2058598294A5031092625 @default.
- W2058598294 hasAuthorship W2058598294A5053145696 @default.
- W2058598294 hasAuthorship W2058598294A5066283050 @default.
- W2058598294 hasAuthorship W2058598294A5082712473 @default.
- W2058598294 hasAuthorship W2058598294A5087047675 @default.
- W2058598294 hasConcept C104317684 @default.
- W2058598294 hasConcept C119056186 @default.
- W2058598294 hasConcept C123012128 @default.
- W2058598294 hasConcept C134018914 @default.
- W2058598294 hasConcept C150903083 @default.
- W2058598294 hasConcept C153911025 @default.
- W2058598294 hasConcept C159654299 @default.
- W2058598294 hasConcept C202751555 @default.
- W2058598294 hasConcept C203014093 @default.
- W2058598294 hasConcept C207001950 @default.
- W2058598294 hasConcept C22615655 @default.
- W2058598294 hasConcept C2776992346 @default.
- W2058598294 hasConcept C2778236600 @default.
- W2058598294 hasConcept C54009773 @default.
- W2058598294 hasConcept C54355233 @default.
- W2058598294 hasConcept C553184892 @default.
- W2058598294 hasConcept C55493867 @default.
- W2058598294 hasConcept C74864618 @default.
- W2058598294 hasConcept C79879829 @default.
- W2058598294 hasConcept C81885089 @default.
- W2058598294 hasConcept C86803240 @default.
- W2058598294 hasConcept C95444343 @default.
- W2058598294 hasConceptScore W2058598294C104317684 @default.
- W2058598294 hasConceptScore W2058598294C119056186 @default.
- W2058598294 hasConceptScore W2058598294C123012128 @default.
- W2058598294 hasConceptScore W2058598294C134018914 @default.
- W2058598294 hasConceptScore W2058598294C150903083 @default.
- W2058598294 hasConceptScore W2058598294C153911025 @default.
- W2058598294 hasConceptScore W2058598294C159654299 @default.