FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058620880> ?p ?o ?g. }

• W2058620880 endingPage "225" @default.
• W2058620880 startingPage "215" @default.
• W2058620880 abstract "The pathogenesis of acute pancreatitis (AP) is still poorly understood. Thus, a reliable pharmacological therapy is currently lacking. In recent years, an impairment of the energy metabolism of pancreatic acinar cells, caused by Ca 2+ -mediated depolarization of the inner mitochondrial membrane and a decreased ATP supply, has been implicated as an important pathological event. In this study, we investigated whether quercetin exerts protection against mitochondrial dysfunction. Following treatment with or without quercetin, rat pancreatic acinar cells were stimulated with supramaximal cholecystokinin-8 (CCK). CCK caused a decrease in the mitochondrial membrane potential (MMP) and ATP concentration, whereas the mitochondrial dehydrogenase activity was significantly increased. Quercetin treatment before CCK application exerted no protection on MMP but increased ATP to a normal level, leading to a continuous decrease in the dehydrogenase activity. The protective effect of quercetin on mitochondrial function was accompanied by a reduction in CCK-induced changes to the cell membrane. Concerning the molecular mechanism underlying the protective effect of quercetin, an increased AMP/ATP ratio suggests that the AMP-activated protein kinase system may be activated. In addition, quercetin strongly inhibited CCK-induced trypsin activity. The results indicate that the use of quercetin may be a therapeutic strategy for reducing the severity of AP." @default.
• W2058620880 created "2016-06-24" @default.
• W2058620880 creator A5021871287 @default.
• W2058620880 creator A5050100977 @default.
• W2058620880 creator A5056937628 @default.
• W2058620880 creator A5084391274 @default.
• W2058620880 date "2014-03-01" @default.
• W2058620880 modified "2023-09-26" @default.
• W2058620880 title "Beneficial effect of the bioflavonoid quercetin on cholecystokinin-induced mitochondrial dysfunction in isolated rat pancreatic acinar cells" @default.
• W2058620880 cites W1534471339 @default.
• W2058620880 cites W1965192208 @default.
• W2058620880 cites W1966051958 @default.
• W2058620880 cites W1966706887 @default.
• W2058620880 cites W1972873422 @default.
• W2058620880 cites W1978462156 @default.
• W2058620880 cites W1979189704 @default.
• W2058620880 cites W1981147590 @default.
• W2058620880 cites W1987447550 @default.
• W2058620880 cites W1996186110 @default.
• W2058620880 cites W1996423113 @default.
• W2058620880 cites W1999635152 @default.
• W2058620880 cites W2008389348 @default.
• W2058620880 cites W2020040871 @default.
• W2058620880 cites W2021186229 @default.
• W2058620880 cites W2023683272 @default.
• W2058620880 cites W2026761064 @default.
• W2058620880 cites W2033479732 @default.
• W2058620880 cites W2037029417 @default.
• W2058620880 cites W2043498277 @default.
• W2058620880 cites W2050332606 @default.
• W2058620880 cites W2050508551 @default.
• W2058620880 cites W2051910399 @default.
• W2058620880 cites W2053866453 @default.
• W2058620880 cites W2059490455 @default.
• W2058620880 cites W2064240173 @default.
• W2058620880 cites W2067136301 @default.
• W2058620880 cites W2069729213 @default.
• W2058620880 cites W2074717002 @default.
• W2058620880 cites W2076952328 @default.
• W2058620880 cites W2076998598 @default.
• W2058620880 cites W2078272726 @default.
• W2058620880 cites W2078344434 @default.
• W2058620880 cites W2081027528 @default.
• W2058620880 cites W2084002409 @default.
• W2058620880 cites W2084714587 @default.
• W2058620880 cites W2092340487 @default.
• W2058620880 cites W2093997858 @default.
• W2058620880 cites W2095157997 @default.
• W2058620880 cites W2101257942 @default.
• W2058620880 cites W2104501200 @default.
• W2058620880 cites W2107101475 @default.
• W2058620880 cites W2110328606 @default.
• W2058620880 cites W2111322904 @default.
• W2058620880 cites W2125173745 @default.
• W2058620880 cites W2137387994 @default.
• W2058620880 cites W2140230248 @default.
• W2058620880 cites W2161247453 @default.
• W2058620880 doi "https://doi.org/10.1139/cjpp-2013-0112" @default.
• W2058620880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24593786" @default.
• W2058620880 hasPublicationYear "2014" @default.
• W2058620880 type Work @default.
• W2058620880 sameAs 2058620880 @default.
• W2058620880 citedByCount "5" @default.
• W2058620880 countsByYear W20586208802015 @default.
• W2058620880 countsByYear W20586208802017 @default.
• W2058620880 countsByYear W20586208802018 @default.
• W2058620880 countsByYear W20586208802023 @default.
• W2058620880 crossrefType "journal-article" @default.
• W2058620880 hasAuthorship W2058620880A5021871287 @default.
• W2058620880 hasAuthorship W2058620880A5050100977 @default.
• W2058620880 hasAuthorship W2058620880A5056937628 @default.
• W2058620880 hasAuthorship W2058620880A5084391274 @default.
• W2058620880 hasConcept C126322002 @default.
• W2058620880 hasConcept C134018914 @default.
• W2058620880 hasConcept C170493617 @default.
• W2058620880 hasConcept C181911157 @default.
• W2058620880 hasConcept C185592680 @default.
• W2058620880 hasConcept C2777593968 @default.
• W2058620880 hasConcept C2778004101 @default.
• W2058620880 hasConcept C2778764654 @default.
• W2058620880 hasConcept C2781263971 @default.
• W2058620880 hasConcept C28859421 @default.
• W2058620880 hasConcept C2991930265 @default.
• W2058620880 hasConcept C32110497 @default.
• W2058620880 hasConcept C55493867 @default.
• W2058620880 hasConcept C71924100 @default.
• W2058620880 hasConcept C86803240 @default.
• W2058620880 hasConcept C98274493 @default.
• W2058620880 hasConceptScore W2058620880C126322002 @default.
• W2058620880 hasConceptScore W2058620880C134018914 @default.
• W2058620880 hasConceptScore W2058620880C170493617 @default.
• W2058620880 hasConceptScore W2058620880C181911157 @default.
• W2058620880 hasConceptScore W2058620880C185592680 @default.
• W2058620880 hasConceptScore W2058620880C2777593968 @default.
• W2058620880 hasConceptScore W2058620880C2778004101 @default.
• W2058620880 hasConceptScore W2058620880C2778764654 @default.
• W2058620880 hasConceptScore W2058620880C2781263971 @default.
• W2058620880 hasConceptScore W2058620880C28859421 @default.

• next