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- W2058628321 abstract "Mutations of the p53 tumour suppressor gene on chromosome 17p are a common genetic change in the malignant progression of many cancers. Here we report a case of a 71-year-old man with haematological, cytofluorimetric and cytochemical findings consistent with a 'de novo' M2 acute myeloid leukaemia (AML). A complex karyotype including a whole chromosome 17 and a t(17;?) (p11;?) was present in 8 of 10 metaphases of bone marrow cells. Southern blot analysis of the bone marrow DNA showed a specific loss of p53 gene in the AML cells. As far as we know, this is the first report of a deletion of both p53 alleles in leukaemia. The effect of the loss of p53 on the course of AML is discussed." @default.
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- W2058628321 date "1994-01-01" @default.
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- W2058628321 title "Total loss of p53 DNA sequences in acute myeloid leukaemia" @default.
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- W2058628321 doi "https://doi.org/10.1016/0145-2126(94)90011-6" @default.
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