FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058641246> ?p ?o ?g. }

• W2058641246 endingPage "13" @default.
• W2058641246 startingPage "1" @default.
• W2058641246 abstract "Abstract The peculiar localization of body cavity lymphomas implies a specific contribution of the intracavitary microenvironment to the pathogenesis of these tumors. In this study, primary effusion lymphoma ( PEL ) was used as a model of body cavity lymphoma to investigate the role of mesothelial cells, which line the serous cavities, in lymphoma progression. The crosstalk between mesothelial and lymphomatous cells was studied in cocultures of primary human mesothelial cells ( HMC ) with PEL cells and a xenograft mouse model of peritoneal PEL . PEL cells were found to induce type 2 epithelial–mesenchymal transition ( EMT ) in HMC , which converted into a myofibroblastic phenotype characterized by loss of epithelial markers (pan cytokeratin and E‐cadherin), expression of EMT ‐associated transcriptional repressors (Snail1, Slug, Zeb1, Sip1), and acquisition of α‐smooth muscle actin (α‐ SMA ), a mesenchymal protein. A progressive thickening of serosal membranes was observed in vivo, accompanied by loss of cytokeratin staining and appearance of α‐ SMA ‐expressing cells, confirming that fibrosis occurred during intracavitary PEL development. On the other hand, HMC were found to modulate PEL cell turnover in vitro, increasing their resistance to apoptosis and proliferation. This supportive activity on PEL cells was retained after transdifferentiation, and was impaired by interferon‐α 2 b treatment. On the whole, our results indicate that PEL cells induce type 2 EMT in HMC , which support PEL cell growth and survival, providing a milieu favorable to lymphoma progression. Our findings provide new clues into the mechanisms involved in lymphoma progression and may indicate new targets for effective treatment of malignant effusions growing in body cavities." @default.
• W2058641246 created "2016-06-24" @default.
• W2058641246 creator A5001293265 @default.
• W2058641246 creator A5016781807 @default.
• W2058641246 creator A5016870943 @default.
• W2058641246 creator A5052125092 @default.
• W2058641246 creator A5052223562 @default.
• W2058641246 creator A5076631534 @default.
• W2058641246 creator A5080827554 @default.
• W2058641246 date "2013-11-19" @default.
• W2058641246 modified "2023-10-09" @default.
• W2058641246 title "Crosstalk between the mesothelium and lymphomatous cells: insight into the mechanisms involved in the progression of body cavity lymphomas" @default.
• W2058641246 cites W1967278331 @default.
• W2058641246 cites W1977442432 @default.
• W2058641246 cites W1984930214 @default.
• W2058641246 cites W1990561688 @default.
• W2058641246 cites W2006176534 @default.
• W2058641246 cites W2007540708 @default.
• W2058641246 cites W2009925378 @default.
• W2058641246 cites W2015779295 @default.
• W2058641246 cites W2020669063 @default.
• W2058641246 cites W2027842929 @default.
• W2058641246 cites W2040938204 @default.
• W2058641246 cites W2042278523 @default.
• W2058641246 cites W2048238795 @default.
• W2058641246 cites W2052149761 @default.
• W2058641246 cites W2060245754 @default.
• W2058641246 cites W2073729398 @default.
• W2058641246 cites W2083122108 @default.
• W2058641246 cites W2087164555 @default.
• W2058641246 cites W2087367170 @default.
• W2058641246 cites W2087757614 @default.
• W2058641246 cites W2088876544 @default.
• W2058641246 cites W2093566798 @default.
• W2058641246 cites W2106400976 @default.
• W2058641246 cites W2117814548 @default.
• W2058641246 cites W2119092367 @default.
• W2058641246 cites W2134570979 @default.
• W2058641246 cites W2135723969 @default.
• W2058641246 cites W2140551998 @default.
• W2058641246 cites W2154589460 @default.
• W2058641246 cites W2154992334 @default.
• W2058641246 cites W2156041649 @default.
• W2058641246 cites W2166589385 @default.
• W2058641246 cites W2174253746 @default.
• W2058641246 cites W2315551924 @default.
• W2058641246 cites W2316067769 @default.
• W2058641246 cites W2336241188 @default.
• W2058641246 cites W4230010647 @default.
• W2058641246 doi "https://doi.org/10.1002/cam4.159" @default.
• W2058641246 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3930384" @default.
• W2058641246 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24402744" @default.
• W2058641246 hasPublicationYear "2013" @default.
• W2058641246 type Work @default.
• W2058641246 sameAs 2058641246 @default.
• W2058641246 citedByCount "9" @default.
• W2058641246 countsByYear W20586412462015 @default.
• W2058641246 countsByYear W20586412462017 @default.
• W2058641246 countsByYear W20586412462018 @default.
• W2058641246 countsByYear W20586412462020 @default.
• W2058641246 countsByYear W20586412462021 @default.
• W2058641246 crossrefType "journal-article" @default.
• W2058641246 hasAuthorship W2058641246A5001293265 @default.
• W2058641246 hasAuthorship W2058641246A5016781807 @default.
• W2058641246 hasAuthorship W2058641246A5016870943 @default.
• W2058641246 hasAuthorship W2058641246A5052125092 @default.
• W2058641246 hasAuthorship W2058641246A5052223562 @default.
• W2058641246 hasAuthorship W2058641246A5076631534 @default.
• W2058641246 hasAuthorship W2058641246A5080827554 @default.
• W2058641246 hasBestOaLocation W20586412461 @default.
• W2058641246 hasConcept C104317684 @default.
• W2058641246 hasConcept C105702510 @default.
• W2058641246 hasConcept C121608353 @default.
• W2058641246 hasConcept C127561419 @default.
• W2058641246 hasConcept C142724271 @default.
• W2058641246 hasConcept C204232928 @default.
• W2058641246 hasConcept C2778536324 @default.
• W2058641246 hasConcept C2779012181 @default.
• W2058641246 hasConcept C2779256057 @default.
• W2058641246 hasConcept C2779338263 @default.
• W2058641246 hasConcept C2779594685 @default.
• W2058641246 hasConcept C2779747549 @default.
• W2058641246 hasConcept C2909640154 @default.
• W2058641246 hasConcept C502942594 @default.
• W2058641246 hasConcept C54355233 @default.
• W2058641246 hasConcept C55493867 @default.
• W2058641246 hasConcept C71924100 @default.
• W2058641246 hasConcept C76419328 @default.
• W2058641246 hasConcept C86803240 @default.
• W2058641246 hasConceptScore W2058641246C104317684 @default.
• W2058641246 hasConceptScore W2058641246C105702510 @default.
• W2058641246 hasConceptScore W2058641246C121608353 @default.
• W2058641246 hasConceptScore W2058641246C127561419 @default.
• W2058641246 hasConceptScore W2058641246C142724271 @default.
• W2058641246 hasConceptScore W2058641246C204232928 @default.
• W2058641246 hasConceptScore W2058641246C2778536324 @default.
• W2058641246 hasConceptScore W2058641246C2779012181 @default.
• W2058641246 hasConceptScore W2058641246C2779256057 @default.

• next