FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058643788> ?p ?o ?g. }

• W2058643788 endingPage "358" @default.
• W2058643788 startingPage "350" @default.
• W2058643788 abstract "Hepatitis C virus (HCV) infection is a leading cause of chronic hepatitis, end-stage liver disease, and hepatocellular carcinoma throughout the world. Considerable evidence indicates that the risk of viral persistence, natural history, and response to antiviral therapy varies among racial groups, but limited data exist on potential mechanisms to account for these differences. Type 1 helper (Th1) responses to HCV proteins and cytomegalovirus (CMV) antigens were examined using a sensitive interferon (IFN)-γ enzyme-linked immunospot (ELISPOT) assay in 187 Caucasian American (CA) and 187 African American (AA) patients with chronic genotype 1 infection. ELISPOT responses were examined relative to human leukocyte antigen (HLA) class II alleles and outcome of therapy with pegylated IFN and ribavirin. Th1 responses specific to hepatitis C core protein and combined HCV antigens were significantly lower in AAs compared to CAs, but CMV responses were comparable in the 2 races. The HCV difference in immunity remained after adjusting for gender, serum alanine aminotransferase, histologic severity, and viral level, and was not accounted for by the differential prevalence of human leukocyte antigen class II alleles. Pretreatment total HCV-specific CD4+ T cell response was associated with sustained virologic response (SVR) to pegylated IFN and ribavirin; 43% of patients who had more than 168 ELISPOTs/106 peripheral blood mononuclear cells (above background) experienced SVR compared to 28% of those who did not (P= 0.007). ELISPOT response was independently associated with SVR by multivariable analysis. Conclusion: Compared to CAs, AAs have weaker HCV-specific immunity. Pretreatment HCV-specific immunity is associated with response to combination antiviral therapy. (HEPATOLOGY 2007.)" @default.
• W2058643788 created "2016-06-24" @default.
• W2058643788 creator A5012197289 @default.
• W2058643788 creator A5012634933 @default.
• W2058643788 creator A5026429291 @default.
• W2058643788 creator A5027689213 @default.
• W2058643788 creator A5030617710 @default.
• W2058643788 creator A5034475527 @default.
• W2058643788 creator A5036674976 @default.
• W2058643788 creator A5071397560 @default.
• W2058643788 date "2007-08-01" @default.
• W2058643788 modified "2023-09-30" @default.
• W2058643788 title "Selective decrease in hepatitis C virus-specific immunity among African Americans and outcome of antiviral therapy" @default.
• W2058643788 cites W1981517725 @default.
• W2058643788 cites W1983657144 @default.
• W2058643788 cites W1984175031 @default.
• W2058643788 cites W1984269473 @default.
• W2058643788 cites W1985234901 @default.
• W2058643788 cites W1985680307 @default.
• W2058643788 cites W1992332433 @default.
• W2058643788 cites W1993008672 @default.
• W2058643788 cites W1994134432 @default.
• W2058643788 cites W2008102007 @default.
• W2058643788 cites W2009050437 @default.
• W2058643788 cites W2018964760 @default.
• W2058643788 cites W2026208522 @default.
• W2058643788 cites W2028145691 @default.
• W2058643788 cites W2028161109 @default.
• W2058643788 cites W2048744193 @default.
• W2058643788 cites W2085388521 @default.
• W2058643788 cites W2092290968 @default.
• W2058643788 cites W2108221283 @default.
• W2058643788 cites W2110755408 @default.
• W2058643788 cites W2111044696 @default.
• W2058643788 cites W2112669742 @default.
• W2058643788 cites W2113026795 @default.
• W2058643788 cites W2115281102 @default.
• W2058643788 cites W2115956200 @default.
• W2058643788 cites W2117184091 @default.
• W2058643788 cites W2118362622 @default.
• W2058643788 cites W2119168386 @default.
• W2058643788 cites W2124588431 @default.
• W2058643788 cites W2130121394 @default.
• W2058643788 cites W2134825316 @default.
• W2058643788 cites W2153941399 @default.
• W2058643788 cites W2168911689 @default.
• W2058643788 cites W2169874096 @default.
• W2058643788 cites W2314619766 @default.
• W2058643788 cites W2321119966 @default.
• W2058643788 doi "https://doi.org/10.1002/hep.21714" @default.
• W2058643788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17659573" @default.
• W2058643788 hasPublicationYear "2007" @default.
• W2058643788 type Work @default.
• W2058643788 sameAs 2058643788 @default.
• W2058643788 citedByCount "57" @default.
• W2058643788 countsByYear W20586437882012 @default.
• W2058643788 countsByYear W20586437882013 @default.
• W2058643788 countsByYear W20586437882014 @default.
• W2058643788 countsByYear W20586437882015 @default.
• W2058643788 countsByYear W20586437882016 @default.
• W2058643788 countsByYear W20586437882017 @default.
• W2058643788 countsByYear W20586437882018 @default.
• W2058643788 countsByYear W20586437882019 @default.
• W2058643788 crossrefType "journal-article" @default.
• W2058643788 hasAuthorship W2058643788A5012197289 @default.
• W2058643788 hasAuthorship W2058643788A5012634933 @default.
• W2058643788 hasAuthorship W2058643788A5026429291 @default.
• W2058643788 hasAuthorship W2058643788A5027689213 @default.
• W2058643788 hasAuthorship W2058643788A5030617710 @default.
• W2058643788 hasAuthorship W2058643788A5034475527 @default.
• W2058643788 hasAuthorship W2058643788A5036674976 @default.
• W2058643788 hasAuthorship W2058643788A5071397560 @default.
• W2058643788 hasConcept C142462285 @default.
• W2058643788 hasConcept C147483822 @default.
• W2058643788 hasConcept C159047783 @default.
• W2058643788 hasConcept C203014093 @default.
• W2058643788 hasConcept C2522874641 @default.
• W2058643788 hasConcept C2776090121 @default.
• W2058643788 hasConcept C2776408679 @default.
• W2058643788 hasConcept C2776455275 @default.
• W2058643788 hasConcept C2776461080 @default.
• W2058643788 hasConcept C2779053233 @default.
• W2058643788 hasConcept C2779341262 @default.
• W2058643788 hasConcept C2780040827 @default.
• W2058643788 hasConcept C71924100 @default.
• W2058643788 hasConcept C8891405 @default.
• W2058643788 hasConceptScore W2058643788C142462285 @default.
• W2058643788 hasConceptScore W2058643788C147483822 @default.
• W2058643788 hasConceptScore W2058643788C159047783 @default.
• W2058643788 hasConceptScore W2058643788C203014093 @default.
• W2058643788 hasConceptScore W2058643788C2522874641 @default.
• W2058643788 hasConceptScore W2058643788C2776090121 @default.
• W2058643788 hasConceptScore W2058643788C2776408679 @default.
• W2058643788 hasConceptScore W2058643788C2776455275 @default.
• W2058643788 hasConceptScore W2058643788C2776461080 @default.
• W2058643788 hasConceptScore W2058643788C2779053233 @default.
• W2058643788 hasConceptScore W2058643788C2779341262 @default.
• W2058643788 hasConceptScore W2058643788C2780040827 @default.

• next