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- W2058647640 abstract "TrkC receptor isoforms have been identified by cDNA cloning and RT-PCR analysis of embryonic chick brain RNA. An N-terminal truncation motif is missing from the signal sequence and first cysteine cluster of the extracellular domain. Within the cytoplasmic dimain, a kinase truncation motif retains part of the kinase domain, but appeared to lack activity. Finally, a kinase insert (KI) motif introduces a 25 amino acid sequence distinct from the known mammalian inserts. KI receptors, like full-length receptors, were tyrosine phosphorylated in response to NT-3 and mediated the transformation of chick embryo fibroblasts and process outgrowth from rat PC12 cells. However, KI receptors supported little, if any, survival of serum-deprived PC12 cells. These results indicate that alternative splicing of trkC transcripts is an important mechanism for regulating cellular responses to NT-3." @default.
- W2058647640 created "2016-06-24" @default.
- W2058647640 creator A5046419579 @default.
- W2058647640 creator A5081145914 @default.
- W2058647640 date "1994-08-01" @default.
- W2058647640 modified "2023-10-13" @default.
- W2058647640 title "Isoforms of the avian TrkC receptor: A novel kinase insertion dissociates transformation and process outgrowth from survival" @default.
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- W2058647640 doi "https://doi.org/10.1016/0896-6273(94)90360-3" @default.
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