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- W2058651606 abstract "We have recently reported that Helicobacter pylori strains expressing the virulence factor cytotoxin-associated gene A (CagA) stimulate increased levels of spermine oxidase (SMO) in gastric epithelial cells, while cagA– strains did not. SMO catabolizes the polyamine spermine and produces H2O2 that results in both apoptosis and DNA damage. Exogenous overexpression of CagA confirmed these findings, and knockdown or inhibition of SMO blocked CagA-mediated apoptosis and DNA damage. The strong association of SMO, apoptosis, and DNA damage was also demonstrated in humans infected with cagA+, but not cagA– strains. In infected gerbils and mice, DNA damage was CagA-dependent and only present in epithelial cells that expressed SMO. We also discovered SMOhigh gastric epithelial cells from infected animals with dysplasia that are resistant to apoptosis despite high levels of DNA damage. Inhibition of polyamine synthesis or SMO could abrogate the development of this cell population that may represent precursors for neoplastic transformation." @default.
- W2058651606 created "2016-06-24" @default.
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- W2058651606 date "2012-01-01" @default.
- W2058651606 modified "2023-10-18" @default.
- W2058651606 title "Spermine oxidase, a polyamine catabolic enzyme that links<i>Helicobacter pylori</i>CagA and gastric cancer risk" @default.
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- W2058651606 doi "https://doi.org/10.4161/gmic.19345" @default.
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