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- W2058658048 abstract "Introduction: Patients with Hodgkin’s lymphoma (HL) that has relapsed after autologous stem cell transplant have few therapeutic options. Patients with CD30-positive T-cell lymphoma similarly have few effective treatment options. Brentuximab vedotin (BV) is an antibody–drug conjugate, which has demonstrated impressive efficacy and safety in both of these histologies.Areas covered: BV was approved for the treatment of relapsed and refractory HL and anaplastic large cell lymphoma in the USA in 2011 and the European Union in 2012. This review focuses on the pivotal Phase II studies, which led to approval of BV, as well as more recent research focusing on the incorporation of this agent into salvage and first-line chemotherapy.Expert opinion: Early phase studies investigating BV in first-line therapy as well as a component of salvage therapy have shown promise. The increased use of BV will depend on positive results in several large, ongoing, randomized Phase III trials. BV may have a role in maintenance therapy going forward as a randomized controlled trial shows a progression-free survival benefit, but no overall survival benefit thus far. Preliminary data in diffuse large B-cell lymphoma have been promising and further studies are underway." @default.
- W2058658048 created "2016-06-24" @default.
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- W2058658048 date "2015-04-14" @default.
- W2058658048 modified "2023-10-16" @default.
- W2058658048 title "Brentuximab vedotin for the treatment of Hodgkin’s and non-Hodgkin’s lymphoma" @default.
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- W2058658048 doi "https://doi.org/10.1517/21678707.2015.1036028" @default.
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