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• W2058658618 abstract "Background The increase in CD4 count may reach a plateau after some duration of virological response to highly active antiretroviral therapy (HAART). Methods A total of 1281 HIV‐infected patients initiating HAART were enrolled in the AntiPROtease (APROCO) cohort. We investigated determinants of increase in CD4 count using longitudinal mixed models in patients who maintained a plasma HIV RNA <500 HIV‐1 RNA copies/mL. Results A total of 870 patients had a virological response at month 4. The median follow‐up time was 57 months. Mean estimated increases in CD4 count in patients with persistent virological response were 29.9 cells/μL/month before month 4, 6.4 cells/μL/month between months 4 and 36, and 0.7 cells/μL/month (not significantly different from 0) after month 36. Three factors were associated with a significantly positive CD4 count slope after month 36: male gender (+0.9), no history of antiretroviral therapy at baseline (+1.7) and baseline CD4 count <100 cells/μL (+2.6). In patients who maintained a virological response after 5 years of HAART, a CD4 count >500 cells/μL was achieved in 83% of those with a baseline CD4 count ≥200 cells/μL and in 45% of those with a baseline CD4 count <200 cells/μL. Conclusion The increase in CD4 count reaches a plateau after 3 years of virological response. Even if patients initiating HAART with low CD4 counts still show a CD4 count increase after 3 years, it remains insufficient to overcome immune deficiency in all patients." @default.
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• W2058658618 date "2007-04-01" @default.
• W2058658618 modified "2023-10-10" @default.
• W2058658618 title "Long-term evolution of CD4 count in patients with a plasma HIV RNA persistently <500 copies/mL during treatment with antiretroviral drugs" @default.
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• W2058658618 doi "https://doi.org/10.1111/j.1468-1293.2007.00446.x" @default.
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