FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058660571> ?p ?o ?g. }

• W2058660571 endingPage "1177" @default.
• W2058660571 startingPage "1170" @default.
• W2058660571 abstract "Prolonged exposure to cannabinoids results in desensitization of cannabinoid receptors. Here, we compared the desensitization produced by the partial agonist, Δ9-tetrahydrocannabinol (THC) to that produced by the full agonist Win55,212-2 on cannabinoid-mediated inhibition of glutamatergic synaptic transmission. Synaptic activity between rat hippocampal neurons was determined from network-driven increases in the intracellular Ca2+ concentration ([Ca2+]i spikes). To assess the effects of prolonged treatment, cultures were incubated with cannabinoids, washed in 0.5% fatty-acid-free bovine serum albumin to ensure the removal of the lipophilic drug and then tested for inhibition of [Ca2+]i spiking by Win55,212-2. In control experiments, 0.1 μM Win55,212-2 inhibited [Ca2+]i spiking by 93 ± 5%. Win55,212-2 produced significantly less inhibition of [Ca2+]i spiking following 18–24 h treatment with 1 μM THC (48 ± 5%) or treatment with 1 μM Win55,212-2 (29 ± 6%). Thus, THC produced significantly less functional desensitization than Win55,212-2. The desensitization produced by THC was maximal at 0.3 μM, remained stable between 1 and 7 days of preincubation and shifted the EC50 of acute inhibition by Win55,212-2 from 27 to 251 nM. Differences in the long-term effects of cannabinoid receptor agonists on synaptic transmission may prove important for evaluating their therapeutic and abuse potential." @default.
• W2058660571 created "2016-06-24" @default.
• W2058660571 creator A5022712140 @default.
• W2058660571 creator A5038294089 @default.
• W2058660571 creator A5084490884 @default.
• W2058660571 date "2005-12-01" @default.
• W2058660571 modified "2023-10-16" @default.
• W2058660571 title "Δ9-Tetrahydrocannabinol-induced desensitization of cannabinoid-mediated inhibition of synaptic transmission between hippocampal neurons in culture" @default.
• W2058660571 cites W1627321564 @default.
• W2058660571 cites W1648000881 @default.
• W2058660571 cites W1830687359 @default.
• W2058660571 cites W1890012419 @default.
• W2058660571 cites W1890934405 @default.
• W2058660571 cites W1967147959 @default.
• W2058660571 cites W1988662183 @default.
• W2058660571 cites W2004142971 @default.
• W2058660571 cites W2006824774 @default.
• W2058660571 cites W2023976332 @default.
• W2058660571 cites W2031231765 @default.
• W2058660571 cites W2033430037 @default.
• W2058660571 cites W2052643496 @default.
• W2058660571 cites W2080280737 @default.
• W2058660571 cites W2096203089 @default.
• W2058660571 cites W2103746754 @default.
• W2058660571 cites W2115792198 @default.
• W2058660571 cites W2123694707 @default.
• W2058660571 cites W2133702956 @default.
• W2058660571 cites W2135970284 @default.
• W2058660571 cites W2141260882 @default.
• W2058660571 cites W2145440062 @default.
• W2058660571 cites W2149601015 @default.
• W2058660571 cites W2156052800 @default.
• W2058660571 cites W2174925893 @default.
• W2058660571 cites W2239360134 @default.
• W2058660571 cites W340599019 @default.
• W2058660571 doi "https://doi.org/10.1016/j.neuropharm.2005.07.012" @default.
• W2058660571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16157354" @default.
• W2058660571 hasPublicationYear "2005" @default.
• W2058660571 type Work @default.
• W2058660571 sameAs 2058660571 @default.
• W2058660571 citedByCount "24" @default.
• W2058660571 countsByYear W20586605712012 @default.
• W2058660571 countsByYear W20586605712014 @default.
• W2058660571 countsByYear W20586605712015 @default.
• W2058660571 countsByYear W20586605712016 @default.
• W2058660571 countsByYear W20586605712018 @default.
• W2058660571 countsByYear W20586605712019 @default.
• W2058660571 countsByYear W20586605712020 @default.
• W2058660571 countsByYear W20586605712021 @default.
• W2058660571 countsByYear W20586605712023 @default.
• W2058660571 crossrefType "journal-article" @default.
• W2058660571 hasAuthorship W2058660571A5022712140 @default.
• W2058660571 hasAuthorship W2058660571A5038294089 @default.
• W2058660571 hasAuthorship W2058660571A5084490884 @default.
• W2058660571 hasConcept C148001335 @default.
• W2058660571 hasConcept C170493617 @default.
• W2058660571 hasConcept C185592680 @default.
• W2058660571 hasConcept C200170125 @default.
• W2058660571 hasConcept C2778563155 @default.
• W2058660571 hasConcept C2778938600 @default.
• W2058660571 hasConcept C2779779143 @default.
• W2058660571 hasConcept C2780648746 @default.
• W2058660571 hasConcept C2780871563 @default.
• W2058660571 hasConcept C55493867 @default.
• W2058660571 hasConcept C61174792 @default.
• W2058660571 hasConcept C86803240 @default.
• W2058660571 hasConcept C98274493 @default.
• W2058660571 hasConceptScore W2058660571C148001335 @default.
• W2058660571 hasConceptScore W2058660571C170493617 @default.
• W2058660571 hasConceptScore W2058660571C185592680 @default.
• W2058660571 hasConceptScore W2058660571C200170125 @default.
• W2058660571 hasConceptScore W2058660571C2778563155 @default.
• W2058660571 hasConceptScore W2058660571C2778938600 @default.
• W2058660571 hasConceptScore W2058660571C2779779143 @default.
• W2058660571 hasConceptScore W2058660571C2780648746 @default.
• W2058660571 hasConceptScore W2058660571C2780871563 @default.
• W2058660571 hasConceptScore W2058660571C55493867 @default.
• W2058660571 hasConceptScore W2058660571C61174792 @default.
• W2058660571 hasConceptScore W2058660571C86803240 @default.
• W2058660571 hasConceptScore W2058660571C98274493 @default.
• W2058660571 hasIssue "8" @default.
• W2058660571 hasLocation W20586605711 @default.
• W2058660571 hasOpenAccess W2058660571 @default.
• W2058660571 hasPrimaryLocation W20586605711 @default.
• W2058660571 hasRelatedWork W1539504782 @default.
• W2058660571 hasRelatedWork W1927830536 @default.
• W2058660571 hasRelatedWork W1967119923 @default.
• W2058660571 hasRelatedWork W1976426436 @default.
• W2058660571 hasRelatedWork W1982062268 @default.
• W2058660571 hasRelatedWork W2058660571 @default.
• W2058660571 hasRelatedWork W2059363316 @default.
• W2058660571 hasRelatedWork W2156052800 @default.
• W2058660571 hasRelatedWork W2948019734 @default.
• W2058660571 hasRelatedWork W4229004415 @default.
• W2058660571 hasVolume "49" @default.
• W2058660571 isParatext "false" @default.
• W2058660571 isRetracted "false" @default.
• W2058660571 magId "2058660571" @default.

• next