FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058661005> ?p ?o ?g. }

• W2058661005 endingPage "573" @default.
• W2058661005 startingPage "563" @default.
• W2058661005 abstract "The immediate-early (IE) promoter of human cytomegalovirus (HCMV) constitutes a primary genetic switch, which determines the progression of viral infection. Earlier reports by others have shown mitogen-activated protein kinase kinase kinase-1 (MEKK1) to be able to up-regulate HCMV-IE promoter through downstream mitogen-activated protein kinase (MAPK) pathways. However, we noticed that the activation of the HCMV-IE promoter by constitutively active MEKK1 (MEKK1-TRU) might not be through the MAPK pathways. Using a HCMV-IE enhancer/promoter (- 522 to + 72) driving a luciferase reporter, we demonstrated that the downstream MAPK activation actually repressed the up-regulation of the promoter by MEKK1 in CHO-K1 and human 293 cells. We further found that the up-regulation of HCMV-IE promoter by MEKK1 could be in great extent suppressed by over-expression of IkappaBalpha. Deletion of the NFkappaB/rel sites in the HCMV-IE enhancer region by mutagenesis proportionally reduced the transcriptional activation by MEKK1-TRU, whereas deletion of the ATF/CREB binding sites or cyclic AMP response elements (CRE) had no effects. Furthermore, the NFkappaB/rel deletion mutant also showed repression on the basic transcription activity of the HCMV-IE promoter. Our results indicate that the NFkappaB/rel sites are not only responsible for the modulation of HCMV-IE enhancer activity by MEKK1 but also control the basic transcription activity of the HCMV-IE promoter. On the other hand, the four consensus CRE sites were found to have no function in the activation of the promoter by MEKK1." @default.
• W2058661005 created "2016-06-24" @default.
• W2058661005 creator A5005079101 @default.
• W2058661005 creator A5007397725 @default.
• W2058661005 creator A5007718947 @default.
• W2058661005 creator A5046844677 @default.
• W2058661005 creator A5053315986 @default.
• W2058661005 creator A5069988129 @default.
• W2058661005 date "2001-01-01" @default.
• W2058661005 modified "2023-10-16" @default.
• W2058661005 title "Modulation of human cytomegalovirus immediate-early gene enhancer by mitogen-activated protein kinase kinase kinase-1" @default.
• W2058661005 cites W142428048 @default.
• W2058661005 cites W1497679878 @default.
• W2058661005 cites W1524972657 @default.
• W2058661005 cites W1788439002 @default.
• W2058661005 cites W1897756474 @default.
• W2058661005 cites W1899552864 @default.
• W2058661005 cites W1933815796 @default.
• W2058661005 cites W1978068747 @default.
• W2058661005 cites W1979343286 @default.
• W2058661005 cites W1984751884 @default.
• W2058661005 cites W1986559713 @default.
• W2058661005 cites W2003362851 @default.
• W2058661005 cites W2020591967 @default.
• W2058661005 cites W2033245328 @default.
• W2058661005 cites W2048159577 @default.
• W2058661005 cites W2067893274 @default.
• W2058661005 cites W2082355820 @default.
• W2058661005 cites W2094401414 @default.
• W2058661005 cites W2097228095 @default.
• W2058661005 cites W2104324075 @default.
• W2058661005 cites W2119310960 @default.
• W2058661005 cites W2121542842 @default.
• W2058661005 cites W2125045982 @default.
• W2058661005 cites W2137385309 @default.
• W2058661005 cites W2142084214 @default.
• W2058661005 cites W31124784 @default.
• W2058661005 doi "https://doi.org/10.1002/jcb.1251" @default.
• W2058661005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11746500" @default.
• W2058661005 hasPublicationYear "2001" @default.
• W2058661005 type Work @default.
• W2058661005 sameAs 2058661005 @default.
• W2058661005 citedByCount "17" @default.
• W2058661005 countsByYear W20586610052012 @default.
• W2058661005 countsByYear W20586610052015 @default.
• W2058661005 countsByYear W20586610052016 @default.
• W2058661005 countsByYear W20586610052018 @default.
• W2058661005 crossrefType "journal-article" @default.
• W2058661005 hasAuthorship W2058661005A5005079101 @default.
• W2058661005 hasAuthorship W2058661005A5007397725 @default.
• W2058661005 hasAuthorship W2058661005A5007718947 @default.
• W2058661005 hasAuthorship W2058661005A5046844677 @default.
• W2058661005 hasAuthorship W2058661005A5053315986 @default.
• W2058661005 hasAuthorship W2058661005A5069988129 @default.
• W2058661005 hasConcept C101762097 @default.
• W2058661005 hasConcept C104317684 @default.
• W2058661005 hasConcept C111936080 @default.
• W2058661005 hasConcept C137361374 @default.
• W2058661005 hasConcept C150194340 @default.
• W2058661005 hasConcept C153911025 @default.
• W2058661005 hasConcept C1629964 @default.
• W2058661005 hasConcept C184235292 @default.
• W2058661005 hasConcept C2779555244 @default.
• W2058661005 hasConcept C2779820661 @default.
• W2058661005 hasConcept C54355233 @default.
• W2058661005 hasConcept C57074206 @default.
• W2058661005 hasConcept C86339819 @default.
• W2058661005 hasConcept C86803240 @default.
• W2058661005 hasConcept C90934575 @default.
• W2058661005 hasConcept C95444343 @default.
• W2058661005 hasConcept C97029542 @default.
• W2058661005 hasConceptScore W2058661005C101762097 @default.
• W2058661005 hasConceptScore W2058661005C104317684 @default.
• W2058661005 hasConceptScore W2058661005C111936080 @default.
• W2058661005 hasConceptScore W2058661005C137361374 @default.
• W2058661005 hasConceptScore W2058661005C150194340 @default.
• W2058661005 hasConceptScore W2058661005C153911025 @default.
• W2058661005 hasConceptScore W2058661005C1629964 @default.
• W2058661005 hasConceptScore W2058661005C184235292 @default.
• W2058661005 hasConceptScore W2058661005C2779555244 @default.
• W2058661005 hasConceptScore W2058661005C2779820661 @default.
• W2058661005 hasConceptScore W2058661005C54355233 @default.
• W2058661005 hasConceptScore W2058661005C57074206 @default.
• W2058661005 hasConceptScore W2058661005C86339819 @default.
• W2058661005 hasConceptScore W2058661005C86803240 @default.
• W2058661005 hasConceptScore W2058661005C90934575 @default.
• W2058661005 hasConceptScore W2058661005C95444343 @default.
• W2058661005 hasConceptScore W2058661005C97029542 @default.
• W2058661005 hasIssue "4" @default.
• W2058661005 hasLocation W20586610051 @default.
• W2058661005 hasLocation W20586610052 @default.
• W2058661005 hasOpenAccess W2058661005 @default.
• W2058661005 hasPrimaryLocation W20586610051 @default.
• W2058661005 hasRelatedWork W1498079934 @default.
• W2058661005 hasRelatedWork W1528562972 @default.
• W2058661005 hasRelatedWork W1811191752 @default.
• W2058661005 hasRelatedWork W1975675866 @default.
• W2058661005 hasRelatedWork W2032500888 @default.

• next