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- W2058671708 abstract "Abstract Over 350 million people are chronically infected by the hepatitis B virus (CHB) worldwide. Three quarters of them are Asian, infected by vertical route or early horizontal transmission. Their quality of life is affected. The chance of shortened life expectancy is substantial. Men in their prime are particularly vulnerable to complications of cirrhosis and hepatocellular carcinoma. Management of cirrhosis is expensive and drains healthcare dollars. The answer to the question—‘Is it better to treat chronic hepatitis B as early as possible?’ is an obvious ‘YES’! Effective therapy is available to change this gloomy prospect. Many potentially more efficacious and safe therapies are in the pipeline. We must capitalize the therapeutic impact in time. The argument for early treatment is particularly strong in following clinical situations: 1 All viraemic CHB children should be treated since there are no predictors of lifetime disease progression. This will also prevent transmission of CHB among children. 2 Adults with viraemic CHB should be treated early for the same reason. The added sense of urgency is to prevent sexual transmission that may result in symptomatic acute hepatitis B and also to reduce the stigma that may lead to discrimination in the society and disadvantage in their career. 3 During acute exacerbation of CHB, early therapy may improve prognosis. 4 CHB patients with active hepatitis should be treated early to prevent complications. With availability of more effective therapeutic agents and regimens, the guidelines for indications to treat are likely to be greatly revised. 5 CHB patients with advanced fibrosis and cirrhosis should be treated as early as possible. There is emerging evidence on prevention of disease progression and prevention of hepatocellular carcinoma in this subgroup of patients." @default.
- W2058671708 created "2016-06-24" @default.
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- W2058671708 date "2004-12-01" @default.
- W2058671708 modified "2023-09-23" @default.
- W2058671708 title "Is it better to treat chronic hepatitis B as early as possible-Pro" @default.
- W2058671708 doi "https://doi.org/10.1111/j.1440-1746.2004.03659.x" @default.
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