Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058676815> ?p ?o ?g. }
- W2058676815 endingPage "12" @default.
- W2058676815 startingPage "3" @default.
- W2058676815 abstract "Apoptotic cell death is initiated by a morphologically homogenous entity that was considered to be non-immunogenic and non-inflammatory in nature. However, recent advances suggest that apoptosis, under certain circumstances, can be immunogenic. In particular, some characteristics of the plasma membrane, acquired at preapoptotic stage, can cause immune effectors to recognize and attack preapoptotic tumor cells. The signals that mediate the immunogenicity of tumor cells involve elements of the DNA damage response (such as ataxia telangiectasia mutated and p53 activation), elements of the endoplasmic reticulum stress response (such as eukaryotic initiation factor 2alpha phosphorylation), as well as elements of the apoptotic response (such as caspase activation). Depending on the signal-transduction pathway, tumor cells responding to chemotherapy or radiotherapy can express 'danger' and 'eat me' signals on the cell surface (such as NKG2D ligands, heat-shock proteins and calreticulin) or can secrete/release immunostimulatory factors (such as cytokines and high-mobility group box 1) to stimulate innate immune effectors. Likewise, the precise sequence of such events influences the 'decision' of the immune system to mount a cognate response or not. We therefore anticipate that the comprehension of the mechanisms governing the immunogenicity of cell death will have a profound impact on the design of anticancer therapies." @default.
- W2058676815 created "2016-06-24" @default.
- W2058676815 creator A5037435178 @default.
- W2058676815 creator A5043463827 @default.
- W2058676815 creator A5056768522 @default.
- W2058676815 creator A5067425961 @default.
- W2058676815 creator A5074612242 @default.
- W2058676815 creator A5088229816 @default.
- W2058676815 date "2007-11-16" @default.
- W2058676815 modified "2023-10-14" @default.
- W2058676815 title "Molecular characteristics of immunogenic cancer cell death" @default.
- W2058676815 cites W1486631729 @default.
- W2058676815 cites W1500228509 @default.
- W2058676815 cites W1515599953 @default.
- W2058676815 cites W1520365933 @default.
- W2058676815 cites W1540090690 @default.
- W2058676815 cites W1541423869 @default.
- W2058676815 cites W1544561961 @default.
- W2058676815 cites W1558109280 @default.
- W2058676815 cites W1561591381 @default.
- W2058676815 cites W1573103899 @default.
- W2058676815 cites W1577698383 @default.
- W2058676815 cites W1600186066 @default.
- W2058676815 cites W1617532721 @default.
- W2058676815 cites W1658591617 @default.
- W2058676815 cites W1661544713 @default.
- W2058676815 cites W1782545213 @default.
- W2058676815 cites W1790055952 @default.
- W2058676815 cites W1877412971 @default.
- W2058676815 cites W1915121024 @default.
- W2058676815 cites W1944631098 @default.
- W2058676815 cites W1945598588 @default.
- W2058676815 cites W1963440056 @default.
- W2058676815 cites W1964420304 @default.
- W2058676815 cites W1964483580 @default.
- W2058676815 cites W1969464492 @default.
- W2058676815 cites W1976065095 @default.
- W2058676815 cites W1978968003 @default.
- W2058676815 cites W1981654979 @default.
- W2058676815 cites W1984068314 @default.
- W2058676815 cites W1986178107 @default.
- W2058676815 cites W1986568749 @default.
- W2058676815 cites W1987074547 @default.
- W2058676815 cites W1987331911 @default.
- W2058676815 cites W1989709588 @default.
- W2058676815 cites W1997054462 @default.
- W2058676815 cites W1998794225 @default.
- W2058676815 cites W2003887174 @default.
- W2058676815 cites W2004266769 @default.
- W2058676815 cites W2004273407 @default.
- W2058676815 cites W2005713983 @default.
- W2058676815 cites W2008513611 @default.
- W2058676815 cites W2009600776 @default.
- W2058676815 cites W2009800174 @default.
- W2058676815 cites W2013705864 @default.
- W2058676815 cites W2016612145 @default.
- W2058676815 cites W2018549526 @default.
- W2058676815 cites W2018917333 @default.
- W2058676815 cites W2019499844 @default.
- W2058676815 cites W2020006960 @default.
- W2058676815 cites W2022500038 @default.
- W2058676815 cites W2028243344 @default.
- W2058676815 cites W2034132952 @default.
- W2058676815 cites W2034269086 @default.
- W2058676815 cites W2037416158 @default.
- W2058676815 cites W2038370680 @default.
- W2058676815 cites W2038918129 @default.
- W2058676815 cites W2039827626 @default.
- W2058676815 cites W2042939195 @default.
- W2058676815 cites W2043642943 @default.
- W2058676815 cites W2044315213 @default.
- W2058676815 cites W2045264627 @default.
- W2058676815 cites W2047003662 @default.
- W2058676815 cites W2047902191 @default.
- W2058676815 cites W2052060514 @default.
- W2058676815 cites W2052853635 @default.
- W2058676815 cites W2059901120 @default.
- W2058676815 cites W2059971436 @default.
- W2058676815 cites W2063192133 @default.
- W2058676815 cites W2063214697 @default.
- W2058676815 cites W2075018537 @default.
- W2058676815 cites W2082559623 @default.
- W2058676815 cites W2086110602 @default.
- W2058676815 cites W2090084038 @default.
- W2058676815 cites W2090750060 @default.
- W2058676815 cites W2091493364 @default.
- W2058676815 cites W2092157690 @default.
- W2058676815 cites W2093424661 @default.
- W2058676815 cites W2094605832 @default.
- W2058676815 cites W2095537212 @default.
- W2058676815 cites W2095736339 @default.
- W2058676815 cites W2097373411 @default.
- W2058676815 cites W2098084836 @default.
- W2058676815 cites W2099317703 @default.
- W2058676815 cites W2100446366 @default.
- W2058676815 cites W2101287778 @default.
- W2058676815 cites W2103544850 @default.
- W2058676815 cites W2107789276 @default.