FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058681208> ?p ?o ?g. }

• W2058681208 endingPage "19" @default.
• W2058681208 startingPage "12" @default.
• W2058681208 abstract "Chemotaxis is the process by which organisms migrate toward nutrients and favorable environments and away from toxins and unfavorable environments. In many species of bacteria, this occurs when extracellular signals are detected by transmembrane receptors and relayed to flagellar motors, which control the cell's swimming behavior.We used a molecularly detailed reaction-kinetics model of the chemotaxis pathway in Escherichia coli coupled to a graphical display based on known swimming parameters to simulate the responses of bacteria to 2D gradients of attractants. The program gives the correct phenotype of over 60 mutants in which chemotaxis-pathway components are deleted or overexpressed and accurately reproduces the responses to pulses and step increases of attractant. In order to match the known sensitivity of bacteria to low concentrations of attractant, we had to introduce a set of infectivity reactions based on cooperative interactions between neighboring chemotaxis receptors in the membrane. In order to match the impulse response to a brief stimulus and to achieve an effective accumulation in a gradient, we also had to increase the activities of the adaptational enzymes CheR and CheB at least an order of magnitude greater than published values. Our simulations reveal that cells develop characteristic levels of receptor methylation and swimming behavior at different positions along a gradient. They also predict a distinctive volcano profile in some gradients, with peaks of cell density at intermediate concentrations of attractant.Our results display the potential use of computer-based bacteria as experimental objects for exploring subtleties of chemotactic behavior." @default.
• W2058681208 created "2016-06-24" @default.
• W2058681208 creator A5065695101 @default.
• W2058681208 creator A5072860052 @default.
• W2058681208 creator A5090336593 @default.
• W2058681208 date "2007-01-01" @default.
• W2058681208 modified "2023-10-14" @default.
• W2058681208 title "The Chemotactic Behavior of Computer-Based Surrogate Bacteria" @default.
• W2058681208 cites W1568106481 @default.
• W2058681208 cites W1972851868 @default.
• W2058681208 cites W1976368335 @default.
• W2058681208 cites W1979581724 @default.
• W2058681208 cites W1989354176 @default.
• W2058681208 cites W1994106464 @default.
• W2058681208 cites W1995884908 @default.
• W2058681208 cites W1999752331 @default.
• W2058681208 cites W2000329555 @default.
• W2058681208 cites W2007500238 @default.
• W2058681208 cites W2029511738 @default.
• W2058681208 cites W2032055589 @default.
• W2058681208 cites W2064441783 @default.
• W2058681208 cites W2072788975 @default.
• W2058681208 cites W2074759798 @default.
• W2058681208 cites W2076795248 @default.
• W2058681208 cites W2111489775 @default.
• W2058681208 cites W2111682035 @default.
• W2058681208 cites W2114368118 @default.
• W2058681208 cites W2114668427 @default.
• W2058681208 cites W2115377824 @default.
• W2058681208 cites W2144736357 @default.
• W2058681208 cites W2149992096 @default.
• W2058681208 cites W2151235051 @default.
• W2058681208 cites W2151722350 @default.
• W2058681208 cites W2169509065 @default.
• W2058681208 doi "https://doi.org/10.1016/j.cub.2006.11.027" @default.
• W2058681208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17208180" @default.
• W2058681208 hasPublicationYear "2007" @default.
• W2058681208 type Work @default.
• W2058681208 sameAs 2058681208 @default.
• W2058681208 citedByCount "93" @default.
• W2058681208 countsByYear W20586812082012 @default.
• W2058681208 countsByYear W20586812082013 @default.
• W2058681208 countsByYear W20586812082014 @default.
• W2058681208 countsByYear W20586812082015 @default.
• W2058681208 countsByYear W20586812082016 @default.
• W2058681208 countsByYear W20586812082017 @default.
• W2058681208 countsByYear W20586812082018 @default.
• W2058681208 countsByYear W20586812082019 @default.
• W2058681208 countsByYear W20586812082020 @default.
• W2058681208 countsByYear W20586812082021 @default.
• W2058681208 countsByYear W20586812082022 @default.
• W2058681208 crossrefType "journal-article" @default.
• W2058681208 hasAuthorship W2058681208A5065695101 @default.
• W2058681208 hasAuthorship W2058681208A5072860052 @default.
• W2058681208 hasAuthorship W2058681208A5090336593 @default.
• W2058681208 hasBestOaLocation W20586812081 @default.
• W2058681208 hasConcept C104317684 @default.
• W2058681208 hasConcept C12554922 @default.
• W2058681208 hasConcept C143065580 @default.
• W2058681208 hasConcept C15744967 @default.
• W2058681208 hasConcept C170493617 @default.
• W2058681208 hasConcept C186060115 @default.
• W2058681208 hasConcept C24530287 @default.
• W2058681208 hasConcept C2779918689 @default.
• W2058681208 hasConcept C28406088 @default.
• W2058681208 hasConcept C523546767 @default.
• W2058681208 hasConcept C54166955 @default.
• W2058681208 hasConcept C542102704 @default.
• W2058681208 hasConcept C54355233 @default.
• W2058681208 hasConcept C547475151 @default.
• W2058681208 hasConcept C55493867 @default.
• W2058681208 hasConcept C86803240 @default.
• W2058681208 hasConcept C95444343 @default.
• W2058681208 hasConceptScore W2058681208C104317684 @default.
• W2058681208 hasConceptScore W2058681208C12554922 @default.
• W2058681208 hasConceptScore W2058681208C143065580 @default.
• W2058681208 hasConceptScore W2058681208C15744967 @default.
• W2058681208 hasConceptScore W2058681208C170493617 @default.
• W2058681208 hasConceptScore W2058681208C186060115 @default.
• W2058681208 hasConceptScore W2058681208C24530287 @default.
• W2058681208 hasConceptScore W2058681208C2779918689 @default.
• W2058681208 hasConceptScore W2058681208C28406088 @default.
• W2058681208 hasConceptScore W2058681208C523546767 @default.
• W2058681208 hasConceptScore W2058681208C54166955 @default.
• W2058681208 hasConceptScore W2058681208C542102704 @default.
• W2058681208 hasConceptScore W2058681208C54355233 @default.
• W2058681208 hasConceptScore W2058681208C547475151 @default.
• W2058681208 hasConceptScore W2058681208C55493867 @default.
• W2058681208 hasConceptScore W2058681208C86803240 @default.
• W2058681208 hasConceptScore W2058681208C95444343 @default.
• W2058681208 hasIssue "1" @default.
• W2058681208 hasLocation W20586812081 @default.
• W2058681208 hasLocation W20586812082 @default.
• W2058681208 hasOpenAccess W2058681208 @default.
• W2058681208 hasPrimaryLocation W20586812081 @default.
• W2058681208 hasRelatedWork W1599006838 @default.
• W2058681208 hasRelatedWork W1917344934 @default.
• W2058681208 hasRelatedWork W1970082812 @default.

• next