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• W2058688009 abstract "Abstract Unidirectional blood‐to‐brain and blood‐to‐tumor transport rate constants for rubidium 82 were determined using dynamic positron emission tomography in patients with primary or metastatic brain tumors. Regional influx rate constants ( K 1 ) and plasma water volume ( V p ) were estimated from the time course of blood and brain radioactivity following a bolus injection of tracer. Eight patients were studied before and 24 to 72 hours after treatment using pharmacological doses of dexamethasone, and 6 additional patients with metastatic brain tumors were studied before and within 60 to 90 minutes after 200‐ to 600‐rad whole‐brain radiation therapy. Steroid treatment was associated with a 9 to 48% decrease in tumor K 1 and a 21% mean decrease in tumor V p . No consistent changes in K 1 or V p were observed in control brain regions. Tumor K 1 and V p did not increase in patients undergoing whole‐brain radiation therapy, all of whom were taking dexamethasone at the time of study. These data suggest that corticosteroids decrease the permeability of tumor capillaries to small hydrophilic molecules (including those of some chemotherapeutic agents) and that steroid pretreatment prevents acute, and potentially dangerous, increases in tumor capillary permeability following cranial irradiation." @default.
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• W2058688009 date "1985-12-01" @default.
• W2058688009 modified "2023-10-16" @default.
• W2058688009 title "Positron emission tomographic measurement of blood-to-brain and blood-to-tumor transport of82Rb: The effect of dexamethasone and whole-brain radiation therapy" @default.
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• W2058688009 doi "https://doi.org/10.1002/ana.410180603" @default.
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