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- W2058688228 abstract "Abstract A simple, high-pressure liquid chromatographic method for determination of bretylium in pharmaceutical dosage forms is described. The sensitivity of the method is 50 ng with high reproducibility. Exogenous additives from injection, infusion or tablet dosage forms do not interfere with the assay. An increase in the pH of the sample, however, caused a decrease in the peak height of bretylium. Bretylium is a chemically stable compound. Under conditions of either 1.5 N hydrochloric acid, nitric acid, or sodium hydroxide at 25°C and 100°C for a period of up to 48 hours did not influence the outcome of the assay." @default.
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- W2058688228 date "1980-01-01" @default.
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- W2058688228 title "Determination of Bretylium in Pharmaceutical Dosage Forms" @default.
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- W2058688228 doi "https://doi.org/10.1080/01483918008060156" @default.
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