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- W2058698189 abstract "Abstract The effect of increasing K+ concentration in CSF on hippocampal neurons was studied by local perfusion of the inferior horn of the lateral ventricle of cats chronically prepared with implanted cannulae and electrodes. Localized paroxysmal discharge appeared from the perfused hippocampus after a latent period of 10–50 min when K+ in the perfusing CSF circulated at a rate of 0.81–1.62 μEq/min. The intensity of discharges was greater and the latent period shorter when K+ in CSF was increased from 8 mEq/liter to 16 mEq/liter. Single shocks delivered to dorsal hippocampus do not induce convulsive activity when K+ in CSF is normal, but induce convulsive activity when delivered during the “latent period” of a perfusion with high K+ CSF. The pattern of discharges suggested a primary action of K+ on basilar dendrites of hippocampal pyramidal cells. DC recording showed spike bursting superimposed on the repolarizing slope of a large negative slow wave indicating a possible disturbance of inhibitory phenomena." @default.
- W2058698189 created "2016-06-24" @default.
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- W2058698189 date "1968-01-01" @default.
- W2058698189 modified "2023-10-18" @default.
- W2058698189 title "Hippocampal epileptic activity induced by localized ventricular perfusion with high-potassium cerebrospinal fluid" @default.
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- W2058698189 doi "https://doi.org/10.1016/0014-4886(68)90126-x" @default.
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