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- W2058706082 abstract "It is generally agreed that β-adrenergic transmitters do not influence the maximum rate of rise of action potentials of cardiac fibers with an intact fast Na+-system. Inhibitory effects of epinephrine have only been reported for a Mg-activated fast current [9]. Fibers with a depressed fast Na+-system have been studied under various experimental conditions, some of them mimicking infarct-like environments [1,5]. In some respects the depressed fast sodium-system reacts differently, e.g. recovery from inactivation [3], Ca2+-effects [10], TTX-influences [6] and susceptibility to antiarrhythmic drug influence [4]. We have studied the influence of isoproterenol, norepinephrine and of phosphodiesterase inhibitors on the depressed fast Na+-system in guinea-pig papillary muscles and gained results which are completely different to those in fibers with intact fast Na+-system." @default.
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- W2058706082 title "Isoproterenol, norepinephrine and phosphodiesterase inhibitors are blockers of the depressed fast Na+-system in ventricular muscle fibers" @default.
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- W2058706082 doi "https://doi.org/10.1016/0022-2828(82)90175-4" @default.
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