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- W2058708539 abstract "Abstract An L1210 leukemia cell line resistant to 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP) (L1210/DDMP) was developed in vivo by treatment of tumor-bearing mice. Resistance to DDMP was confirmed by subsequent in vivo survival experiments and by in vitro dose-response curves. The L1210/DDMP line demonstrated little cross-resistance to another folate analog, methotrexate (MTX). This was confirmed both in vivo , with survival experiments, and in vitro , using dose-response curves. A statistical analysis of the in vivo data confirmed DDMP resistance with lack of MTX cross-resistance. Dihydrofolate reductase (DHFR) activity in the L1210/DDMP/R 5 line was no greater than in the parent cell line (L1210/S). and the K m of DHFR for dihydrofolate was the same in the L1210/DDMP/R 5 and L1210/S lines. The K i for DHFR of the L1210/DDMP/R 5 cell line versus the L1210/S cell line was increased 3.0-fold for MTX and 3.5-fold for DDMP. Total accumulation of [ 14 C]DDMP was identical in the two cell lines. The explanation for the lack of MTX cross-resistance in the L1210/DDMP/R 5 line is unknown." @default.
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- W2058708539 date "1980-08-01" @default.
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- W2058708539 title "Studies with a 2,4-diamino-5-(3',4'-dichlorophenyl)-6-methylpyrimidine (DDMP)-resistant L1210 leukemia cell line without cross-resistance to methotrexate" @default.
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- W2058708539 doi "https://doi.org/10.1016/0006-2952(80)90204-x" @default.
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