FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058709111> ?p ?o ?g. }

• W2058709111 endingPage "4011" @default.
• W2058709111 startingPage "4005" @default.
• W2058709111 abstract "Abstract In human cutaneous malignant melanoma, a predominance of activated mutations in the N-ras gene has been documented. To obtain a mouse model most closely mimicking the human disease, a transgenic mouse line was generated by targeting expression of dominant-active human N-ras (N-RasQ61K) to the melanocyte lineage by tyrosinase regulatory sequences (Tyr::N-RasQ61K). Transgenic mice show hyperpigmented skin and develop cutaneous metastasizing melanoma. Consistent with the tumor suppressor function of the INK4a locus that encodes p16INK4A and p19ARF, &gt;90% of Tyr::N-RasQ61K INK4a−/− transgenic mice develop melanoma at 6 months. Primary melanoma tumors are melanotic, multifocal, microinvade the epidermis or epithelium of hair follicles, and disseminate as metastases to lymph nodes, lung, and liver. Primary melanoma can be transplanted s.c. in nude mice, and if injected i.v. into NOD/SCID mice colonize the lung. In addition, primary melanomas and metastases contain cells expressing the stem cell marker nestin suggesting a hierarchical structure of the tumors comprised of primitive nestin-expressing precursors and differentiated cells. In conclusion, a novel mouse model with melanotic and metastasizing melanoma was obtained by recapitulating genetic lesions frequently found in human melanoma." @default.
• W2058709111 created "2016-06-24" @default.
• W2058709111 creator A5008498964 @default.
• W2058709111 creator A5053617882 @default.
• W2058709111 creator A5061537254 @default.
• W2058709111 creator A5068821173 @default.
• W2058709111 creator A5081397096 @default.
• W2058709111 creator A5081577791 @default.
• W2058709111 date "2005-05-15" @default.
• W2058709111 modified "2023-10-18" @default.
• W2058709111 title "Metastasizing Melanoma Formation Caused by Expression of Activated N-RasQ61K on an INK4a-Deficient Background" @default.
• W2058709111 cites W1483388049 @default.
• W2058709111 cites W1524477650 @default.
• W2058709111 cites W1965124339 @default.
• W2058709111 cites W1972031617 @default.
• W2058709111 cites W1985196783 @default.
• W2058709111 cites W1999441881 @default.
• W2058709111 cites W2002045623 @default.
• W2058709111 cites W2003223749 @default.
• W2058709111 cites W2013740436 @default.
• W2058709111 cites W2017235640 @default.
• W2058709111 cites W2029963379 @default.
• W2058709111 cites W2034459612 @default.
• W2058709111 cites W2037882440 @default.
• W2058709111 cites W2040578305 @default.
• W2058709111 cites W2046231538 @default.
• W2058709111 cites W2049085719 @default.
• W2058709111 cites W2056578809 @default.
• W2058709111 cites W2057394091 @default.
• W2058709111 cites W2060573548 @default.
• W2058709111 cites W2069329357 @default.
• W2058709111 cites W2076506898 @default.
• W2058709111 cites W2081853773 @default.
• W2058709111 cites W2082224552 @default.
• W2058709111 cites W2090604832 @default.
• W2058709111 cites W2102085111 @default.
• W2058709111 cites W2106211503 @default.
• W2058709111 cites W2106983893 @default.
• W2058709111 cites W2110128078 @default.
• W2058709111 cites W2112572166 @default.
• W2058709111 cites W2139402152 @default.
• W2058709111 cites W2147822352 @default.
• W2058709111 cites W2158048826 @default.
• W2058709111 cites W2164947531 @default.
• W2058709111 cites W2274884072 @default.
• W2058709111 cites W71022479 @default.
• W2058709111 doi "https://doi.org/10.1158/0008-5472.can-04-2970" @default.
• W2058709111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15899789" @default.
• W2058709111 hasPublicationYear "2005" @default.
• W2058709111 type Work @default.
• W2058709111 sameAs 2058709111 @default.
• W2058709111 citedByCount "261" @default.
• W2058709111 countsByYear W20587091112012 @default.
• W2058709111 countsByYear W20587091112013 @default.
• W2058709111 countsByYear W20587091112014 @default.
• W2058709111 countsByYear W20587091112015 @default.
• W2058709111 countsByYear W20587091112016 @default.
• W2058709111 countsByYear W20587091112017 @default.
• W2058709111 countsByYear W20587091112018 @default.
• W2058709111 countsByYear W20587091112019 @default.
• W2058709111 countsByYear W20587091112020 @default.
• W2058709111 countsByYear W20587091112021 @default.
• W2058709111 countsByYear W20587091112022 @default.
• W2058709111 countsByYear W20587091112023 @default.
• W2058709111 crossrefType "journal-article" @default.
• W2058709111 hasAuthorship W2058709111A5008498964 @default.
• W2058709111 hasAuthorship W2058709111A5053617882 @default.
• W2058709111 hasAuthorship W2058709111A5061537254 @default.
• W2058709111 hasAuthorship W2058709111A5068821173 @default.
• W2058709111 hasAuthorship W2058709111A5081397096 @default.
• W2058709111 hasAuthorship W2058709111A5081577791 @default.
• W2058709111 hasBestOaLocation W20587091111 @default.
• W2058709111 hasConcept C102230213 @default.
• W2058709111 hasConcept C104317684 @default.
• W2058709111 hasConcept C107538193 @default.
• W2058709111 hasConcept C136834591 @default.
• W2058709111 hasConcept C141035611 @default.
• W2058709111 hasConcept C142724271 @default.
• W2058709111 hasConcept C2777658100 @default.
• W2058709111 hasConcept C2777738006 @default.
• W2058709111 hasConcept C2779769559 @default.
• W2058709111 hasConcept C28328180 @default.
• W2058709111 hasConcept C502942594 @default.
• W2058709111 hasConcept C54355233 @default.
• W2058709111 hasConcept C555283112 @default.
• W2058709111 hasConcept C71924100 @default.
• W2058709111 hasConcept C86803240 @default.
• W2058709111 hasConcept C95444343 @default.
• W2058709111 hasConceptScore W2058709111C102230213 @default.
• W2058709111 hasConceptScore W2058709111C104317684 @default.
• W2058709111 hasConceptScore W2058709111C107538193 @default.
• W2058709111 hasConceptScore W2058709111C136834591 @default.
• W2058709111 hasConceptScore W2058709111C141035611 @default.
• W2058709111 hasConceptScore W2058709111C142724271 @default.
• W2058709111 hasConceptScore W2058709111C2777658100 @default.
• W2058709111 hasConceptScore W2058709111C2777738006 @default.
• W2058709111 hasConceptScore W2058709111C2779769559 @default.
• W2058709111 hasConceptScore W2058709111C28328180 @default.

• next