FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058709849> ?p ?o ?g. }

• W2058709849 endingPage "568" @default.
• W2058709849 startingPage "559" @default.
• W2058709849 abstract "Cerebrovascular reactivity (CVR) can be mapped using BOLD fMRI to provide a clinical insight into vascular health that can be used to diagnose cerebrovascular disease. Breath-holds are a readily accessible method for producing the required arterial CO 2 increases but their implementation into clinical studies is limited by concerns that patients will demonstrate highly variable performance of breath-hold challenges. This study assesses the repeatability of CVR measurements despite poor task performance, to determine if and how robust results could be achieved with breath-holds in patients. Twelve healthy volunteers were scanned at 3T. Six functional scans were acquired, each consisting of 6 breath-hold challenges (10, 15, or 20 s duration) interleaved with periods of paced breathing. These scans simulated the varying breath-hold consistency and ability levels that may occur in patient data. Uniform ramps, time-scaled ramps, and end-tidal CO 2 data were used as regressors in a general linear model in order to measure CVR at the grey matter, regional, and voxelwise level. The intraclass correlation coefficient (ICC) quantified the repeatability of the CVR measurement for each breath-hold regressor type and scale of interest across the variable task performances. The ramp regressors did not fully account for variability in breath-hold performance and did not achieve acceptable repeatability (ICC < 0.4) in several regions analysed. In contrast, the end-tidal CO 2 regressors resulted in “excellent” repeatability (ICC = 0.82) in the average grey matter data, and resulted in acceptable repeatability in all smaller regions tested (ICC > 0.4). Further analysis of intra-subject CVR variability across the brain (ICC spatial and voxelwise correlation) supported the use of end-tidal CO 2 data to extract robust whole-brain CVR maps, despite variability in breath-hold performance. We conclude that the incorporation of end-tidal CO 2 monitoring into scanning enables robust, repeatable measurement of CVR that makes breath-hold challenges suitable for routine clinical practice. • Cerebrovascular reactivity can be measured despite poor breath-hold performance. • Measuring end-tidal CO 2 accounts for varying breath-hold ability and consistency. • Breath-holds can provide CVR maps with “excellent” repeatability. • Breath-holding is a robust tool for assessing vascular health in patient studies." @default.
• W2058709849 created "2016-06-24" @default.
• W2058709849 creator A5022744697 @default.
• W2058709849 creator A5057824637 @default.
• W2058709849 date "2013-12-01" @default.
• W2058709849 modified "2023-09-29" @default.
• W2058709849 title "Reliable quantification of BOLD fMRI cerebrovascular reactivity despite poor breath-hold performance" @default.
• W2058709849 cites W1972939851 @default.
• W2058709849 cites W1978823699 @default.
• W2058709849 cites W2000493336 @default.
• W2058709849 cites W2002660165 @default.
• W2058709849 cites W2012129172 @default.
• W2058709849 cites W2024929829 @default.
• W2058709849 cites W2026390611 @default.
• W2058709849 cites W2028158865 @default.
• W2058709849 cites W2028890762 @default.
• W2058709849 cites W2030162941 @default.
• W2058709849 cites W2030345497 @default.
• W2058709849 cites W2031335742 @default.
• W2058709849 cites W2037589881 @default.
• W2058709849 cites W2050717100 @default.
• W2058709849 cites W2051036431 @default.
• W2058709849 cites W2051998615 @default.
• W2058709849 cites W2057062755 @default.
• W2058709849 cites W2059579942 @default.
• W2058709849 cites W2067610798 @default.
• W2058709849 cites W2068067169 @default.
• W2058709849 cites W2072902092 @default.
• W2058709849 cites W2082724398 @default.
• W2058709849 cites W2090996306 @default.
• W2058709849 cites W2103771964 @default.
• W2058709849 cites W2117140276 @default.
• W2058709849 cites W2122901111 @default.
• W2058709849 cites W2122983695 @default.
• W2058709849 cites W2123605834 @default.
• W2058709849 cites W2126491128 @default.
• W2058709849 cites W2129289310 @default.
• W2058709849 cites W2141403362 @default.
• W2058709849 cites W2143895814 @default.
• W2058709849 cites W2152758478 @default.
• W2058709849 cites W2170117095 @default.
• W2058709849 cites W2345842757 @default.
• W2058709849 cites W4246791114 @default.
• W2058709849 doi "https://doi.org/10.1016/j.neuroimage.2013.07.007" @default.
• W2058709849 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899001" @default.
• W2058709849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23845426" @default.
• W2058709849 hasPublicationYear "2013" @default.
• W2058709849 type Work @default.
• W2058709849 sameAs 2058709849 @default.
• W2058709849 citedByCount "143" @default.
• W2058709849 countsByYear W20587098492013 @default.
• W2058709849 countsByYear W20587098492014 @default.
• W2058709849 countsByYear W20587098492015 @default.
• W2058709849 countsByYear W20587098492016 @default.
• W2058709849 countsByYear W20587098492017 @default.
• W2058709849 countsByYear W20587098492018 @default.
• W2058709849 countsByYear W20587098492019 @default.
• W2058709849 countsByYear W20587098492020 @default.
• W2058709849 countsByYear W20587098492021 @default.
• W2058709849 countsByYear W20587098492022 @default.
• W2058709849 countsByYear W20587098492023 @default.
• W2058709849 crossrefType "journal-article" @default.
• W2058709849 hasAuthorship W2058709849A5022744697 @default.
• W2058709849 hasAuthorship W2058709849A5057824637 @default.
• W2058709849 hasBestOaLocation W20587098492 @default.
• W2058709849 hasConcept C104709138 @default.
• W2058709849 hasConcept C105795698 @default.
• W2058709849 hasConcept C154020017 @default.
• W2058709849 hasConcept C15744967 @default.
• W2058709849 hasConcept C33923547 @default.
• W2058709849 hasConcept C39300077 @default.
• W2058709849 hasConcept C41008148 @default.
• W2058709849 hasConcept C42219234 @default.
• W2058709849 hasConcept C71924100 @default.
• W2058709849 hasConcept C9893847 @default.
• W2058709849 hasConceptScore W2058709849C104709138 @default.
• W2058709849 hasConceptScore W2058709849C105795698 @default.
• W2058709849 hasConceptScore W2058709849C154020017 @default.
• W2058709849 hasConceptScore W2058709849C15744967 @default.
• W2058709849 hasConceptScore W2058709849C33923547 @default.
• W2058709849 hasConceptScore W2058709849C39300077 @default.
• W2058709849 hasConceptScore W2058709849C41008148 @default.
• W2058709849 hasConceptScore W2058709849C42219234 @default.
• W2058709849 hasConceptScore W2058709849C71924100 @default.
• W2058709849 hasConceptScore W2058709849C9893847 @default.
• W2058709849 hasLocation W20587098491 @default.
• W2058709849 hasLocation W20587098492 @default.
• W2058709849 hasLocation W20587098493 @default.
• W2058709849 hasLocation W20587098494 @default.
• W2058709849 hasLocation W20587098495 @default.
• W2058709849 hasOpenAccess W2058709849 @default.
• W2058709849 hasPrimaryLocation W20587098491 @default.
• W2058709849 hasRelatedWork W2004029572 @default.
• W2058709849 hasRelatedWork W2032623487 @default.
• W2058709849 hasRelatedWork W2115239786 @default.
• W2058709849 hasRelatedWork W2117051396 @default.
• W2058709849 hasRelatedWork W2122614767 @default.
• W2058709849 hasRelatedWork W2748952813 @default.

• next