FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058710577> ?p ?o ?g. }

• W2058710577 endingPage "2117" @default.
• W2058710577 startingPage "2111" @default.
• W2058710577 abstract "The tissue factor (TF)- Factor VIIa (FVIIa) complex has a pivotal role in inflammatory and coagulation responses in patients with systemic inflammatory response syndrome (SIRS) and sepsis. Because zymogen FVII (FVII) and FVIIa compete for binding to TF, their plasma levels determine if a catalytically active TF-FVIIa complex will be formed.To study mortality in SIRS patients as a function of FVIIa and FVII levels in plasma.This was a cohort study of 275 patients presenting with SIRS, aged 18 years or older and with an anticipated Intensive Care Unit (ICU) stay of at least 24 h. FVIIa was measured using a novel, quantitative assay that recognizes FVIIa, but not FVII. All-cause hospital mortality was followed over a period of 60 days.The percentage of FVII measured as FVIIa was higher in non-survivors than survivors (2.8%, IQR = 1-5.5% vs. 1.5%, IQR = 0.6-3.3%; P = 0.034). High levels of FVIIa were associated with decreased 60-day cumulative survival (62% vs. 81%, P = 0.030); the opposite was observed for FVII (84% vs. 76%, P = 0.039). Patients with high-FVIIa and low-FVII levels had a three-fold increased hazard ratio (HR) compared with the patients that had low-FVIIa and high-FVII levels (HR = 3.24, 95% confidence interval [CI] = 1.41-7.36). This association persisted after adjusting for the APACHE IV score (adjusted HR = 2.75, 95% CI = 1.2-6.27).SIRS patients with high-FVIIa and low-FVII on admission have an increased mortality risk, an association that is independent from the parameters included in the APACHE IV score." @default.
• W2058710577 created "2016-06-24" @default.
• W2058710577 creator A5014206473 @default.
• W2058710577 creator A5017415110 @default.
• W2058710577 creator A5023268881 @default.
• W2058710577 creator A5025899708 @default.
• W2058710577 creator A5059451655 @default.
• W2058710577 creator A5059549923 @default.
• W2058710577 creator A5064638391 @default.
• W2058710577 creator A5074302578 @default.
• W2058710577 date "2013-12-01" @default.
• W2058710577 modified "2023-09-30" @default.
• W2058710577 title "Increased mortality in systemic inflammatory response syndrome patients with high levels of coagulation factor VIIa" @default.
• W2058710577 cites W1591377255 @default.
• W2058710577 cites W1608358576 @default.
• W2058710577 cites W1854917621 @default.
• W2058710577 cites W194949005 @default.
• W2058710577 cites W1966875441 @default.
• W2058710577 cites W1973758538 @default.
• W2058710577 cites W1993741298 @default.
• W2058710577 cites W2000566182 @default.
• W2058710577 cites W2001280008 @default.
• W2058710577 cites W2020368956 @default.
• W2058710577 cites W2029539300 @default.
• W2058710577 cites W2031154947 @default.
• W2058710577 cites W2038091919 @default.
• W2058710577 cites W2051096704 @default.
• W2058710577 cites W2051174896 @default.
• W2058710577 cites W2053568531 @default.
• W2058710577 cites W2064160073 @default.
• W2058710577 cites W2074210146 @default.
• W2058710577 cites W2083395689 @default.
• W2058710577 cites W2089545220 @default.
• W2058710577 cites W2094158785 @default.
• W2058710577 cites W2108435955 @default.
• W2058710577 cites W2110971703 @default.
• W2058710577 cites W2118375897 @default.
• W2058710577 cites W2118902632 @default.
• W2058710577 cites W2123151246 @default.
• W2058710577 cites W2141817221 @default.
• W2058710577 cites W2289234838 @default.
• W2058710577 doi "https://doi.org/10.1111/jth.12427" @default.
• W2058710577 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24131789" @default.
• W2058710577 hasPublicationYear "2013" @default.
• W2058710577 type Work @default.
• W2058710577 sameAs 2058710577 @default.
• W2058710577 citedByCount "16" @default.
• W2058710577 countsByYear W20587105772014 @default.
• W2058710577 countsByYear W20587105772015 @default.
• W2058710577 countsByYear W20587105772016 @default.
• W2058710577 countsByYear W20587105772017 @default.
• W2058710577 countsByYear W20587105772019 @default.
• W2058710577 countsByYear W20587105772020 @default.
• W2058710577 countsByYear W20587105772023 @default.
• W2058710577 crossrefType "journal-article" @default.
• W2058710577 hasAuthorship W2058710577A5014206473 @default.
• W2058710577 hasAuthorship W2058710577A5017415110 @default.
• W2058710577 hasAuthorship W2058710577A5023268881 @default.
• W2058710577 hasAuthorship W2058710577A5025899708 @default.
• W2058710577 hasAuthorship W2058710577A5059451655 @default.
• W2058710577 hasAuthorship W2058710577A5059549923 @default.
• W2058710577 hasAuthorship W2058710577A5064638391 @default.
• W2058710577 hasAuthorship W2058710577A5074302578 @default.
• W2058710577 hasBestOaLocation W20587105771 @default.
• W2058710577 hasConcept C126322002 @default.
• W2058710577 hasConcept C186738567 @default.
• W2058710577 hasConcept C207103383 @default.
• W2058710577 hasConcept C2778382381 @default.
• W2058710577 hasConcept C2778384902 @default.
• W2058710577 hasConcept C2780930249 @default.
• W2058710577 hasConcept C2781090800 @default.
• W2058710577 hasConcept C2908626413 @default.
• W2058710577 hasConcept C44249647 @default.
• W2058710577 hasConcept C71924100 @default.
• W2058710577 hasConcept C90924648 @default.
• W2058710577 hasConceptScore W2058710577C126322002 @default.
• W2058710577 hasConceptScore W2058710577C186738567 @default.
• W2058710577 hasConceptScore W2058710577C207103383 @default.
• W2058710577 hasConceptScore W2058710577C2778382381 @default.
• W2058710577 hasConceptScore W2058710577C2778384902 @default.
• W2058710577 hasConceptScore W2058710577C2780930249 @default.
• W2058710577 hasConceptScore W2058710577C2781090800 @default.
• W2058710577 hasConceptScore W2058710577C2908626413 @default.
• W2058710577 hasConceptScore W2058710577C44249647 @default.
• W2058710577 hasConceptScore W2058710577C71924100 @default.
• W2058710577 hasConceptScore W2058710577C90924648 @default.
• W2058710577 hasFunder F4320321642 @default.
• W2058710577 hasFunder F4320323596 @default.
• W2058710577 hasIssue "12" @default.
• W2058710577 hasLocation W20587105771 @default.
• W2058710577 hasLocation W20587105772 @default.
• W2058710577 hasOpenAccess W2058710577 @default.
• W2058710577 hasPrimaryLocation W20587105771 @default.
• W2058710577 hasRelatedWork W2019775107 @default.
• W2058710577 hasRelatedWork W2023142863 @default.
• W2058710577 hasRelatedWork W2023412739 @default.
• W2058710577 hasRelatedWork W2031515989 @default.
• W2058710577 hasRelatedWork W2046202266 @default.

• next