FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058712510> ?p ?o ?g. }

• W2058712510 endingPage "100" @default.
• W2058712510 startingPage "87" @default.
• W2058712510 abstract "Neutrophils (PMN) are critical host defense cells that have a role in the pathophysiology of a variety of inflammatory diseases, particularly those diseases associated with antigen-antibody immune complexes (IC) deposited in tissues. Activation of PMN by IC is most efficient if the IC are presented immobilized on a surface. Adhesion to the immobilized IC is important for subsequent activation of PMN effector functions, such as generation of reactive oxygen metabolites. Adhesion of human PMN to immobilized IC requires the expression and activation of adhesion receptors called integrins. Of the integrins expressed on PMN, the beta 2 family has been found to be of particular importance for PMN function. The mechanism of beta 2 integrin activation during adhesion to IC has been studied in human PMN, but not in equine PMN. We show here that adhesion of equine PMN to immobilized IC requires beta 2 integrins. Like adhesion, IC-induced respiratory burst activity is dependent on beta 2 integrins. Furthermore, the signaling pathway triggering beta 2 integrin-dependent adhesion of equine PMN to IC and subsequent generation of respiratory burst activity is inhibited by the specific phosphatidylinositol 3-kinase (PI3K) antagonists wortmannin and LY294002 with IC(50) (concentration at which 50% inhibition is achieved) similar to the published values for inhibition of PI3K enzymatic activity. In contrast, PMA-induced activation of beta 2 integrin-dependent adhesion and respiratory burst activity are wortmannin and LY294002 insensitive. These data demonstrate that like in human PMN, IC-induced activation of beta 2 integrins and beta 2 integrin-dependent functions in equine PMN is dependent on PI3K activity." @default.
• W2058712510 created "2016-06-24" @default.
• W2058712510 creator A5015982903 @default.
• W2058712510 creator A5017829645 @default.
• W2058712510 creator A5056519418 @default.
• W2058712510 date "2001-09-01" @default.
• W2058712510 modified "2023-10-16" @default.
• W2058712510 title "Signaling mechanism for equine neutrophil activation by immune complexes" @default.
• W2058712510 cites W1525061031 @default.
• W2058712510 cites W1529396499 @default.
• W2058712510 cites W1557239654 @default.
• W2058712510 cites W1568605582 @default.
• W2058712510 cites W1589063951 @default.
• W2058712510 cites W1818313483 @default.
• W2058712510 cites W1838131144 @default.
• W2058712510 cites W1896937632 @default.
• W2058712510 cites W1991276398 @default.
• W2058712510 cites W1994957003 @default.
• W2058712510 cites W2002127663 @default.
• W2058712510 cites W2002475242 @default.
• W2058712510 cites W2017190378 @default.
• W2058712510 cites W2037986253 @default.
• W2058712510 cites W2049583989 @default.
• W2058712510 cites W2052954853 @default.
• W2058712510 cites W2055092075 @default.
• W2058712510 cites W2056573320 @default.
• W2058712510 cites W2064705265 @default.
• W2058712510 cites W2079672922 @default.
• W2058712510 cites W2080128214 @default.
• W2058712510 cites W2080274411 @default.
• W2058712510 cites W2082626835 @default.
• W2058712510 cites W2085248087 @default.
• W2058712510 cites W2085668133 @default.
• W2058712510 cites W2089614717 @default.
• W2058712510 cites W2094314261 @default.
• W2058712510 cites W2117174491 @default.
• W2058712510 cites W2139852589 @default.
• W2058712510 cites W2142960215 @default.
• W2058712510 cites W2147441847 @default.
• W2058712510 cites W2157189324 @default.
• W2058712510 doi "https://doi.org/10.1016/s0165-2427(01)00350-6" @default.
• W2058712510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11557296" @default.
• W2058712510 hasPublicationYear "2001" @default.
• W2058712510 type Work @default.
• W2058712510 sameAs 2058712510 @default.
• W2058712510 citedByCount "15" @default.
• W2058712510 countsByYear W20587125102014 @default.
• W2058712510 countsByYear W20587125102015 @default.
• W2058712510 countsByYear W20587125102018 @default.
• W2058712510 countsByYear W20587125102023 @default.
• W2058712510 crossrefType "journal-article" @default.
• W2058712510 hasAuthorship W2058712510A5015982903 @default.
• W2058712510 hasAuthorship W2058712510A5017829645 @default.
• W2058712510 hasAuthorship W2058712510A5056519418 @default.
• W2058712510 hasConcept C1491633281 @default.
• W2058712510 hasConcept C153911025 @default.
• W2058712510 hasConcept C16224149 @default.
• W2058712510 hasConcept C170493617 @default.
• W2058712510 hasConcept C171779818 @default.
• W2058712510 hasConcept C178790620 @default.
• W2058712510 hasConcept C185592680 @default.
• W2058712510 hasConcept C195687474 @default.
• W2058712510 hasConcept C203014093 @default.
• W2058712510 hasConcept C2776912716 @default.
• W2058712510 hasConcept C2778308172 @default.
• W2058712510 hasConcept C2780610907 @default.
• W2058712510 hasConcept C55493867 @default.
• W2058712510 hasConcept C62478195 @default.
• W2058712510 hasConcept C84416704 @default.
• W2058712510 hasConcept C85789140 @default.
• W2058712510 hasConcept C86803240 @default.
• W2058712510 hasConcept C8891405 @default.
• W2058712510 hasConcept C95444343 @default.
• W2058712510 hasConcept C99971728 @default.
• W2058712510 hasConceptScore W2058712510C1491633281 @default.
• W2058712510 hasConceptScore W2058712510C153911025 @default.
• W2058712510 hasConceptScore W2058712510C16224149 @default.
• W2058712510 hasConceptScore W2058712510C170493617 @default.
• W2058712510 hasConceptScore W2058712510C171779818 @default.
• W2058712510 hasConceptScore W2058712510C178790620 @default.
• W2058712510 hasConceptScore W2058712510C185592680 @default.
• W2058712510 hasConceptScore W2058712510C195687474 @default.
• W2058712510 hasConceptScore W2058712510C203014093 @default.
• W2058712510 hasConceptScore W2058712510C2776912716 @default.
• W2058712510 hasConceptScore W2058712510C2778308172 @default.
• W2058712510 hasConceptScore W2058712510C2780610907 @default.
• W2058712510 hasConceptScore W2058712510C55493867 @default.
• W2058712510 hasConceptScore W2058712510C62478195 @default.
• W2058712510 hasConceptScore W2058712510C84416704 @default.
• W2058712510 hasConceptScore W2058712510C85789140 @default.
• W2058712510 hasConceptScore W2058712510C86803240 @default.
• W2058712510 hasConceptScore W2058712510C8891405 @default.
• W2058712510 hasConceptScore W2058712510C95444343 @default.
• W2058712510 hasConceptScore W2058712510C99971728 @default.
• W2058712510 hasIssue "1-2" @default.
• W2058712510 hasLocation W20587125101 @default.
• W2058712510 hasLocation W20587125102 @default.
• W2058712510 hasOpenAccess W2058712510 @default.

• next