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• W2058713492 abstract "In the current treatment era, it is estimated that more than two thirds of children with cancer will achieve long-term survival 1 Sorenson K. Levitt G.A. Bull C. Dorup I. Sullivan I.D. Late anthracycline cardiotoxicity after childhood cancer. Cancer. 2003; 97: 1991-1998 Crossref PubMed Scopus (174) Google Scholar with an estimated number of adult survivors of childhood malignancies exceeding 250,000 in the United States alone. 2 Lipshultz S.E. Rifai N. Dalton V.M. et al. The effect of Dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia. N Engl J Med. 2004; 351: 145-153 Crossref PubMed Scopus (501) Google Scholar Treatment strategies include chemotherapy, radiation, and surgery with up to 65% of children receiving anthracyclines as part of their treatment regimen. Anthracycline cardiotoxicity is a well-known complication resulting from the treatment of childhood malignancies, and is reported to occur in up to 16% of pediatric patients. 3 Krischer J.P. Epstein S. Cuthbertson D.D. et al. Clinical cardiotoxicity following anthracycline treatment for childhood cancer: the pediatric oncology group experience. J Clin Oncol. 1997; 15: 1544-1552 PubMed Google Scholar , 4 Singal P.K. Iliskovic N. Current concepts: doxorubicin-induced cardiomyopathy. N Engl J Med. 1998; 339: 900-905 Crossref PubMed Scopus (1553) Google Scholar Serial surveillance for cardiotoxicity has most commonly focused on the echocardiographic assessment of left ventricular (LV) systolic function using either shortening fraction (FS%) or ejection fraction (EF%). However, changes in echocardiographic ejection phase indices can be late clinical findings in anthracycline cardiotoxicity, and often lag in the early identification of subclinical regional myocardial dysfunction. Therefore, newer noninvasive methodologies to evaluate children receiving anthracyclines enabling identification of early markers of either global or regional myocardial dysfunction are needed." @default.
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• W2058713492 date "2007-05-01" @default.
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• W2058713492 title "Evaluation of Longitudinal Ventricular Function with Tissue Doppler Echocardiography in Children Treated with Anthracyclines" @default.
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• W2058713492 doi "https://doi.org/10.1016/j.echo.2006.10.011" @default.
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