Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058716504> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2058716504 endingPage "1374" @default.
- W2058716504 startingPage "1368" @default.
- W2058716504 abstract "The present studies were performed to determine whether dipeptide absorption in human jejunum exhibits the characteristics of carrier-mediated transport. 15-cm jejunal segments from human volunteers were perfused with test solutions containing varying amounts of either glycylglycine, glycylleucine, glycine, leucine, glycylglycine with leucine or glycine, glycylglycine with glycylleucine, or glycylleucine with an equimolar mixture of free glycine and leucine. Jejunal absorption rates of both glycylglycine and glycylleucine followed the kinetics of a saturable process. The Km value in millimoles/liter of glycylglycine was significantly greater than the Km value of glycylleucine (43.3±2.6 vs. 26.8±5.9, P < 0.05); and the Km value of glycine was also significantly greater than the Km value of leucine (42.7±7.5 vs. 20.4±5.4, P < 0.05). While overlapping occurred among the Km values of free amino acids and dipeptides, the transport kinetics of dipeptides were characterized by higher Vmax values (in micromoles per minute per 15 centimeters) than those of free amino acids. For example, the Vmax values for glycylglycine and glycine were 837±62 and 590±56, respectively (P < 0.02). While jejunal absorption rates of glycylglycine were not significantly affected by free leucine or free glycine, they were competitively inhibited by glycylleucine. The jejunal absorption rate of glycylleucine was not significantly altered by an equimolar mixture of free glycine and leucine. The selective absorption of dipeptides was investigated by infusing three equimolar mixtures, each containing two different dipeptides. Among the three dipeptides examined, glycylglycine was the least absorbed. There was no significant difference between the absorption of glycylleucine and leucylglycine." @default.
- W2058716504 created "2016-06-24" @default.
- W2058716504 creator A5027250757 @default.
- W2058716504 creator A5054415328 @default.
- W2058716504 date "1974-05-01" @default.
- W2058716504 modified "2023-09-29" @default.
- W2058716504 title "Functional Characterization of Dipeptide Transport System in Human Jejunum" @default.
- W2058716504 cites W1514591440 @default.
- W2058716504 cites W1587929517 @default.
- W2058716504 cites W1651027427 @default.
- W2058716504 cites W1767561420 @default.
- W2058716504 cites W1906482623 @default.
- W2058716504 cites W1965138514 @default.
- W2058716504 cites W1966678569 @default.
- W2058716504 cites W1968716069 @default.
- W2058716504 cites W1992666239 @default.
- W2058716504 cites W2003778458 @default.
- W2058716504 cites W2016151789 @default.
- W2058716504 cites W2037334855 @default.
- W2058716504 cites W2038211753 @default.
- W2058716504 cites W2039848829 @default.
- W2058716504 cites W2104406172 @default.
- W2058716504 cites W2130511817 @default.
- W2058716504 cites W2135698256 @default.
- W2058716504 cites W2151760082 @default.
- W2058716504 cites W2157297622 @default.
- W2058716504 cites W2162515033 @default.
- W2058716504 cites W2299122889 @default.
- W2058716504 cites W2310365085 @default.
- W2058716504 cites W2341174992 @default.
- W2058716504 cites W2398720642 @default.
- W2058716504 cites W2405111718 @default.
- W2058716504 cites W2410731849 @default.
- W2058716504 cites W2460596059 @default.
- W2058716504 doi "https://doi.org/10.1172/jci107685" @default.
- W2058716504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/302625" @default.
- W2058716504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4825229" @default.
- W2058716504 hasPublicationYear "1974" @default.
- W2058716504 type Work @default.
- W2058716504 sameAs 2058716504 @default.
- W2058716504 citedByCount "87" @default.
- W2058716504 countsByYear W20587165042013 @default.
- W2058716504 countsByYear W20587165042015 @default.
- W2058716504 countsByYear W20587165042018 @default.
- W2058716504 countsByYear W20587165042020 @default.
- W2058716504 countsByYear W20587165042021 @default.
- W2058716504 countsByYear W20587165042023 @default.
- W2058716504 crossrefType "journal-article" @default.
- W2058716504 hasAuthorship W2058716504A5027250757 @default.
- W2058716504 hasAuthorship W2058716504A5054415328 @default.
- W2058716504 hasBestOaLocation W20587165041 @default.
- W2058716504 hasConcept C185592680 @default.
- W2058716504 hasConcept C2776366702 @default.
- W2058716504 hasConcept C2776580952 @default.
- W2058716504 hasConcept C2777756961 @default.
- W2058716504 hasConcept C2779138802 @default.
- W2058716504 hasConcept C2780139244 @default.
- W2058716504 hasConcept C43617362 @default.
- W2058716504 hasConcept C515207424 @default.
- W2058716504 hasConcept C55493867 @default.
- W2058716504 hasConceptScore W2058716504C185592680 @default.
- W2058716504 hasConceptScore W2058716504C2776366702 @default.
- W2058716504 hasConceptScore W2058716504C2776580952 @default.
- W2058716504 hasConceptScore W2058716504C2777756961 @default.
- W2058716504 hasConceptScore W2058716504C2779138802 @default.
- W2058716504 hasConceptScore W2058716504C2780139244 @default.
- W2058716504 hasConceptScore W2058716504C43617362 @default.
- W2058716504 hasConceptScore W2058716504C515207424 @default.
- W2058716504 hasConceptScore W2058716504C55493867 @default.
- W2058716504 hasIssue "5" @default.
- W2058716504 hasLocation W20587165041 @default.
- W2058716504 hasLocation W20587165042 @default.
- W2058716504 hasLocation W20587165043 @default.
- W2058716504 hasLocation W20587165044 @default.
- W2058716504 hasOpenAccess W2058716504 @default.
- W2058716504 hasPrimaryLocation W20587165041 @default.
- W2058716504 hasRelatedWork W1581557438 @default.
- W2058716504 hasRelatedWork W183886054 @default.
- W2058716504 hasRelatedWork W1972404459 @default.
- W2058716504 hasRelatedWork W2017751304 @default.
- W2058716504 hasRelatedWork W2041846912 @default.
- W2058716504 hasRelatedWork W2058716504 @default.
- W2058716504 hasRelatedWork W2096731535 @default.
- W2058716504 hasRelatedWork W2101345146 @default.
- W2058716504 hasRelatedWork W2109915341 @default.
- W2058716504 hasRelatedWork W2118188397 @default.
- W2058716504 hasVolume "53" @default.
- W2058716504 isParatext "false" @default.
- W2058716504 isRetracted "false" @default.
- W2058716504 magId "2058716504" @default.
- W2058716504 workType "article" @default.