FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058734972> ?p ?o ?g. }

• W2058734972 endingPage "77" @default.
• W2058734972 startingPage "68" @default.
• W2058734972 abstract "Only a subset of cancer patients inoculated with oncolytic herpes simplex virus (oHSV) type-1 has shown objective response in phase 1 and 2 clinical trials. This has raised speculations whether resistance of tumor cells to oHSV therapy may be a limiting factor. In this study, we have identified established and patient derived primary glioblastoma multiforme (GBM) stem cell lines (GSC) resistant to oHSV and also to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) that has recently shown promise in preclinical and initial clinical studies. We created a recombinant oHSV bearing a secretable TRAIL (oHSV-TRAIL) and hypothesized that oHSV-TRAIL could be used as a cancer therapeutic to target a broad spectrum of resistant tumors in a mechanism-based manner. Using the identified resistant GBM lines, we show that oHSV-TRAIL downregulates extracellular signal-regulated protein kinase (ERK)-mitogen-activated protein kinase (MAPK) and upregulates c-Jun N-terminal kinase (JNK) and p38-MAPK signaling, which primes resistant GBM cells to apoptosis via activation of caspase-8, -9, and -3. We further show that oHSV-TRAIL inhibits tumor growth and invasiveness and increases survival of mice bearing resistant intracerebral tumors without affecting the normal tissues. This study sheds new light on the mechanism by which oHSV and TRAIL function in concert to overcome therapeutic-resistance, and provides an oncolytic virus based platform to target a broad spectrum of different cancer types." @default.
• W2058734972 created "2016-06-24" @default.
• W2058734972 creator A5003043220 @default.
• W2058734972 creator A5006633218 @default.
• W2058734972 creator A5011930120 @default.
• W2058734972 creator A5012665450 @default.
• W2058734972 creator A5034567480 @default.
• W2058734972 creator A5045294037 @default.
• W2058734972 creator A5054187553 @default.
• W2058734972 creator A5059949459 @default.
• W2058734972 creator A5065492142 @default.
• W2058734972 date "2013-01-01" @default.
• W2058734972 modified "2023-09-30" @default.
• W2058734972 title "Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors" @default.
• W2058734972 cites W1558969188 @default.
• W2058734972 cites W1605122517 @default.
• W2058734972 cites W1965497380 @default.
• W2058734972 cites W1966542708 @default.
• W2058734972 cites W1970212185 @default.
• W2058734972 cites W1975857526 @default.
• W2058734972 cites W1976385326 @default.
• W2058734972 cites W1978579044 @default.
• W2058734972 cites W1987506447 @default.
• W2058734972 cites W1996777076 @default.
• W2058734972 cites W2000534793 @default.
• W2058734972 cites W2004588222 @default.
• W2058734972 cites W2011062510 @default.
• W2058734972 cites W2016364696 @default.
• W2058734972 cites W2025822934 @default.
• W2058734972 cites W2028074588 @default.
• W2058734972 cites W2036044314 @default.
• W2058734972 cites W2039355845 @default.
• W2058734972 cites W2043797928 @default.
• W2058734972 cites W2045415534 @default.
• W2058734972 cites W2052301777 @default.
• W2058734972 cites W2055875542 @default.
• W2058734972 cites W2057382033 @default.
• W2058734972 cites W2063287389 @default.
• W2058734972 cites W2064752967 @default.
• W2058734972 cites W2069181727 @default.
• W2058734972 cites W2078993865 @default.
• W2058734972 cites W2081236313 @default.
• W2058734972 cites W2085722674 @default.
• W2058734972 cites W2088291142 @default.
• W2058734972 cites W2090732350 @default.
• W2058734972 cites W2092230026 @default.
• W2058734972 cites W2094593855 @default.
• W2058734972 cites W2094949672 @default.
• W2058734972 cites W2096186936 @default.
• W2058734972 cites W2096287682 @default.
• W2058734972 cites W2104605014 @default.
• W2058734972 cites W2109855243 @default.
• W2058734972 cites W2110076327 @default.
• W2058734972 cites W2113363982 @default.
• W2058734972 cites W2127207254 @default.
• W2058734972 cites W2141267324 @default.
• W2058734972 cites W2141433020 @default.
• W2058734972 cites W2143308874 @default.
• W2058734972 cites W2158681922 @default.
• W2058734972 cites W2163598864 @default.
• W2058734972 cites W2165123465 @default.
• W2058734972 cites W2165652424 @default.
• W2058734972 cites W2166624257 @default.
• W2058734972 doi "https://doi.org/10.1038/mt.2012.175" @default.
• W2058734972 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3538303" @default.
• W2058734972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22929661" @default.
• W2058734972 hasPublicationYear "2013" @default.
• W2058734972 type Work @default.
• W2058734972 sameAs 2058734972 @default.
• W2058734972 citedByCount "43" @default.
• W2058734972 countsByYear W20587349722013 @default.
• W2058734972 countsByYear W20587349722014 @default.
• W2058734972 countsByYear W20587349722015 @default.
• W2058734972 countsByYear W20587349722016 @default.
• W2058734972 countsByYear W20587349722017 @default.
• W2058734972 countsByYear W20587349722019 @default.
• W2058734972 countsByYear W20587349722020 @default.
• W2058734972 countsByYear W20587349722021 @default.
• W2058734972 countsByYear W20587349722022 @default.
• W2058734972 countsByYear W20587349722023 @default.
• W2058734972 crossrefType "journal-article" @default.
• W2058734972 hasAuthorship W2058734972A5003043220 @default.
• W2058734972 hasAuthorship W2058734972A5006633218 @default.
• W2058734972 hasAuthorship W2058734972A5011930120 @default.
• W2058734972 hasAuthorship W2058734972A5012665450 @default.
• W2058734972 hasAuthorship W2058734972A5034567480 @default.
• W2058734972 hasAuthorship W2058734972A5045294037 @default.
• W2058734972 hasAuthorship W2058734972A5054187553 @default.
• W2058734972 hasAuthorship W2058734972A5059949459 @default.
• W2058734972 hasAuthorship W2058734972A5065492142 @default.
• W2058734972 hasBestOaLocation W20587349721 @default.
• W2058734972 hasConcept C121608353 @default.
• W2058734972 hasConcept C159047783 @default.
• W2058734972 hasConcept C184235292 @default.
• W2058734972 hasConcept C190283241 @default.
• W2058734972 hasConcept C3020616263 @default.
• W2058734972 hasConcept C502942594 @default.
• W2058734972 hasConcept C54355233 @default.

• next