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- W2058736766 abstract "BACKGROUND: Lipid-enveloped viruses such as HIV, HBV, and HCV can be inactivated by treatment with solvents and detergents. HAV and human parvovirus B19 lack lipid envelopes and are not inactivated. Solvent/detergent-treated pooled plasma (S/D plasma) contains neutralizing antibodies, but it is not known whether the parvovirus B19 antibody content is sufficient to prevent transmission of the disease. A patient is described who developed a clinical illness due to parvovirus B19 infection after the infusion of S/D plasma. CASE REPORT: A 36-year-old woman with myasthenia gravis underwent five plasma exchange procedures from January 15 to January 25, 1999, using albumin, except for 5 units of SD plasma given because of a low fibrinogen level. Four of the 5 units were implicated in a recall after high levels of parvovirus B19 DNA were found in several lots. Two weeks after the infusion, the patient developed fatigue, a rash, and severe polyarthralgias. Parvovirus B19 IgG and IgM antibody titers were consistent with an apos infection. CONCLUSION: Clinically apparent parvovirus B19 infection can follow the use of S/D plasma that contains high levels of parvovirus B19 DNA." @default.
- W2058736766 created "2016-06-24" @default.
- W2058736766 creator A5015010692 @default.
- W2058736766 creator A5077230562 @default.
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- W2058736766 date "2000-10-01" @default.
- W2058736766 modified "2023-09-27" @default.
- W2058736766 title "Clinical illness due to parvovirus B19 infection after infusion of solvent/detergent-treated pooled plasma" @default.
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- W2058736766 doi "https://doi.org/10.1046/j.1537-2995.2000.40101203.x" @default.
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