Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058741114> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2058741114 abstract "Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by immune cell entry into the brain. In normal conditions, this infiltration of immune cells is prevented by the blood–brain barrier (BBB) which is characterized by highly specialized endothelial cells. Therefore, the BBB is of high importance for brain protection and homeostasis. However, during inflammatory processes, like the ones observed in the course of MS, the BBB is dysfunctional and leaky, allowing the entry of serum proteins and immune cells into the brain, aggravating lesion formation. Notch signaling is a pathway essential for proper vascular development; however its role during adult vascular homeostasis and during inflammation is not clearly understood. Several research groups have shown that during inflammatory conditions Notch signaling is altered in endothelial cells, hinting for a function of this pathway during inflammation. Therefore, we hypothesize that Notch signaling is involved in BBB function during homeostasis and during inflammatory processes. Here we show that inflammation alters Notch receptors and ligand expression in brain endothelial cells. Furthermore, when Notch signaling is inhibited, brain endothelial cells show a decrease in barrier function as demonstrated by decreased resistance and increased permeability of endothelial monolayers to fluorescent molecules. During inflammatory conditions we observe an even more pronounced effect, demonstrating the importance of Notch signaling in coping with inflammation. These results were also confirmed by the Notch receptors knockdown in brain endothelial cells. In addition, our results show that Notch ligands are important during migration processes of T cells through the brain vasculature. Taken together our results demonstrate the importance of Notch signaling in BBB homeostasis and function. We believe that by understanding how BBB function is regulated, we can develop targeted therapies to the brain vasculature and restore its function during disease." @default.
- W2058741114 created "2016-06-24" @default.
- W2058741114 creator A5020818564 @default.
- W2058741114 creator A5035090143 @default.
- W2058741114 creator A5043918204 @default.
- W2058741114 creator A5053379363 @default.
- W2058741114 creator A5054106492 @default.
- W2058741114 creator A5062348668 @default.
- W2058741114 creator A5072787977 @default.
- W2058741114 creator A5088140495 @default.
- W2058741114 date "2014-10-01" @default.
- W2058741114 modified "2023-09-27" @default.
- W2058741114 title "Notch receptors and ligands mediate barrier function in brain endothelial cells" @default.
- W2058741114 doi "https://doi.org/10.1016/j.jneuroim.2014.08.084" @default.
- W2058741114 hasPublicationYear "2014" @default.
- W2058741114 type Work @default.
- W2058741114 sameAs 2058741114 @default.
- W2058741114 citedByCount "0" @default.
- W2058741114 crossrefType "journal-article" @default.
- W2058741114 hasAuthorship W2058741114A5020818564 @default.
- W2058741114 hasAuthorship W2058741114A5035090143 @default.
- W2058741114 hasAuthorship W2058741114A5043918204 @default.
- W2058741114 hasAuthorship W2058741114A5053379363 @default.
- W2058741114 hasAuthorship W2058741114A5054106492 @default.
- W2058741114 hasAuthorship W2058741114A5062348668 @default.
- W2058741114 hasAuthorship W2058741114A5072787977 @default.
- W2058741114 hasAuthorship W2058741114A5088140495 @default.
- W2058741114 hasConcept C113045295 @default.
- W2058741114 hasConcept C123012128 @default.
- W2058741114 hasConcept C134018914 @default.
- W2058741114 hasConcept C161879069 @default.
- W2058741114 hasConcept C169760540 @default.
- W2058741114 hasConcept C170493617 @default.
- W2058741114 hasConcept C202751555 @default.
- W2058741114 hasConcept C203014093 @default.
- W2058741114 hasConcept C2776914184 @default.
- W2058741114 hasConcept C2778402981 @default.
- W2058741114 hasConcept C529278444 @default.
- W2058741114 hasConcept C55493867 @default.
- W2058741114 hasConcept C62478195 @default.
- W2058741114 hasConcept C63645605 @default.
- W2058741114 hasConcept C65114990 @default.
- W2058741114 hasConcept C86803240 @default.
- W2058741114 hasConcept C8891405 @default.
- W2058741114 hasConcept C95444343 @default.
- W2058741114 hasConceptScore W2058741114C113045295 @default.
- W2058741114 hasConceptScore W2058741114C123012128 @default.
- W2058741114 hasConceptScore W2058741114C134018914 @default.
- W2058741114 hasConceptScore W2058741114C161879069 @default.
- W2058741114 hasConceptScore W2058741114C169760540 @default.
- W2058741114 hasConceptScore W2058741114C170493617 @default.
- W2058741114 hasConceptScore W2058741114C202751555 @default.
- W2058741114 hasConceptScore W2058741114C203014093 @default.
- W2058741114 hasConceptScore W2058741114C2776914184 @default.
- W2058741114 hasConceptScore W2058741114C2778402981 @default.
- W2058741114 hasConceptScore W2058741114C529278444 @default.
- W2058741114 hasConceptScore W2058741114C55493867 @default.
- W2058741114 hasConceptScore W2058741114C62478195 @default.
- W2058741114 hasConceptScore W2058741114C63645605 @default.
- W2058741114 hasConceptScore W2058741114C65114990 @default.
- W2058741114 hasConceptScore W2058741114C86803240 @default.
- W2058741114 hasConceptScore W2058741114C8891405 @default.
- W2058741114 hasConceptScore W2058741114C95444343 @default.
- W2058741114 hasLocation W20587411141 @default.
- W2058741114 hasOpenAccess W2058741114 @default.
- W2058741114 hasPrimaryLocation W20587411141 @default.
- W2058741114 hasRelatedWork W1483700701 @default.
- W2058741114 hasRelatedWork W149446254 @default.
- W2058741114 hasRelatedWork W1963680784 @default.
- W2058741114 hasRelatedWork W199191306 @default.
- W2058741114 hasRelatedWork W2035399583 @default.
- W2058741114 hasRelatedWork W2038541687 @default.
- W2058741114 hasRelatedWork W2114957660 @default.
- W2058741114 hasRelatedWork W2137101980 @default.
- W2058741114 hasRelatedWork W2317997742 @default.
- W2058741114 hasRelatedWork W2481714679 @default.
- W2058741114 hasRelatedWork W2567030997 @default.
- W2058741114 hasRelatedWork W2589247641 @default.
- W2058741114 hasRelatedWork W2780949810 @default.
- W2058741114 hasRelatedWork W2893029745 @default.
- W2058741114 hasRelatedWork W2917521450 @default.
- W2058741114 hasRelatedWork W2983907715 @default.
- W2058741114 hasRelatedWork W3045577253 @default.
- W2058741114 hasRelatedWork W3091416909 @default.
- W2058741114 hasRelatedWork W3095017990 @default.
- W2058741114 hasRelatedWork W3132835140 @default.
- W2058741114 isParatext "false" @default.
- W2058741114 isRetracted "false" @default.
- W2058741114 magId "2058741114" @default.
- W2058741114 workType "article" @default.