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• W2058743721 abstract "Increased understanding of the molecular processes associated with the dysplasia–adenocarcinoma sequence linked to Barrett’s esophagus may be beneficial for early tumor detection and refined diagnosis as well as for improved prognostication. We applied immunohistochemical staining for the markers Ki-67, p53, β-catenin and E-cadherin in order to evaluate their prognostic importance in 59 Barrett’s esophagus-associated adenocarcinomas. Reduced or absent membranous E-cadherin staining was identified in 75% of the tumors and predicted poor prognosis in manova (hazard ratio [HR] 3.3, P = 0.05). The small subset of tumors with low levels (< 10%) of Ki-67 staining showed a worse prognosis (HR 3.2, P < 0.01), whereas immunostaining for p53 and β-catenin showed no correlation with prognosis. Deranged cell adhesion has been demonstrated to be an early event in tumor development. The down-regulation of E-cadherin and its prognostic importance indicate that cell adhesion may be a prime area for targeted therapies in esophageal adenocarcinoma." @default.
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• W2058743721 date "2008-04-01" @default.
• W2058743721 modified "2023-10-18" @default.
• W2058743721 title "Prognostic value of cell adhesion in esophageal adenocarcinomas" @default.
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• W2058743721 doi "https://doi.org/10.1111/j.1442-2050.2007.00749.x" @default.
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