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- W2058745978 abstract "In day-old chicks trained on the one-trial taste-avoidance task, activation of NMDA receptors by glutamate is particularly important in the initial stages of memory consolidation. In addition, acetylcholine receptor activation has been shown to be a necessary component of memory formation for this task because injection of scopolamine produces amnesia. Memantine, a non-competitive NMDA receptor antagonist, improves memory formation under certain impairing circumstances, despite inhibiting the activation of NMDA receptors. The present experiments tested the hypothesis that memantine can ameliorate scopolamine-induced amnesia in day-old chicks (Gallus gallus domesticus) trained on the one-trial taste-avoidance task. Three experiments assessed the effects of scopolamine, memantine, and glutamate in this task. The results of Experiment 1 demonstrated that 50.0mM scopolamine produces significant amnesia. In Experiment 2, 1.0mM memantine reversed the scopolamine-induced amnesia, while other doses were ineffective. In Experiment 3, injection of 50.0mM glutamate in combination with scopolamine reversed the memantine amelioration. These results indicate a relationship between glutamate and acetylcholine in memory formation in the day-old chick." @default.
- W2058745978 created "2016-06-24" @default.
- W2058745978 creator A5048319403 @default.
- W2058745978 creator A5062081460 @default.
- W2058745978 date "2010-05-01" @default.
- W2058745978 modified "2023-10-16" @default.
- W2058745978 title "Memantine ameliorates scopolamine-induced amnesia in chicks trained on taste-avoidance learning" @default.
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- W2058745978 doi "https://doi.org/10.1016/j.nlm.2010.02.001" @default.
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