Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058746051> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2058746051 endingPage "1281" @default.
- W2058746051 startingPage "1279" @default.
- W2058746051 abstract "Sulphasalazine extends remissions and lessens disease activity during relapses of ulcerative colitis, but it also causes many adverse side-effects. The adverse reactions are mostly attributable to the sulphapyridine carrier moiety rather than the active principle 5-aminosalicylic acid (5-ASA), so agents to deliver 5-ASA to the colon by other means have been designed. We have compared the efficacy and tolerability of two such agents, olsalazine and mesalazine, in maintenance therapy of ulcerative colitis. 100 patients with ulcerative colitis in remission were recruited at one centre and assigned randomly to treatment with olsalazine (Dipentum; 1·0 g daily) or mesalazine (Asacol, with Eudragit-S coating; 1·2 g daily). Compliance, biochemical and haematological variables, and clinical evidence of disease activity were assessed every 3 months for 12 months by observers unaware of treatment allocation. In intention-to-treat analysis, which included as treatment failures patients withdrawn for protocol violations, adverse reactions, intercurrent illness, or non-compliance as well as those with relapses of ulcerative colitis, the olsalazine group had a significantly lower rate of treatment failure than the mesalazine group (12/49 [24%] vs 23/50 [46%]; p=0·025). Analysis restricted to 64 patients still in remission at 1 year and 18 with relapses also showed a significant difference in relapse rate (olsalazine 5/42 [12%] vs mesalazine 13/40 [33%]; p = 0·024). Both drugs were well tolerated; only 9 patients reported substantial side-effects. Olsalazine was clearly superior to mesalazine in prevention of relapses in ulcerative colitis, especially in patients with left-sided disease." @default.
- W2058746051 created "2016-06-24" @default.
- W2058746051 creator A5027651090 @default.
- W2058746051 creator A5036974253 @default.
- W2058746051 creator A5040331916 @default.
- W2058746051 creator A5062382964 @default.
- W2058746051 creator A5076408981 @default.
- W2058746051 creator A5079336377 @default.
- W2058746051 creator A5081838665 @default.
- W2058746051 date "1992-05-01" @default.
- W2058746051 modified "2023-09-27" @default.
- W2058746051 title "Randomised comparison of olsalazine and mesalazine in prevention of relapses in ulcerative colitis" @default.
- W2058746051 cites W1497617769 @default.
- W2058746051 cites W1504656450 @default.
- W2058746051 cites W1964233609 @default.
- W2058746051 cites W1974348321 @default.
- W2058746051 cites W1978865468 @default.
- W2058746051 cites W2010759737 @default.
- W2058746051 cites W2019657479 @default.
- W2058746051 cites W2024513902 @default.
- W2058746051 cites W2044507601 @default.
- W2058746051 cites W2050077474 @default.
- W2058746051 cites W2055179541 @default.
- W2058746051 cites W2056817635 @default.
- W2058746051 cites W2065780155 @default.
- W2058746051 cites W2070450416 @default.
- W2058746051 cites W2081067304 @default.
- W2058746051 cites W2090568923 @default.
- W2058746051 cites W2096326818 @default.
- W2058746051 cites W2107729707 @default.
- W2058746051 cites W2114959701 @default.
- W2058746051 cites W2129196336 @default.
- W2058746051 cites W2142157038 @default.
- W2058746051 cites W2158858344 @default.
- W2058746051 cites W2411840308 @default.
- W2058746051 cites W2412588445 @default.
- W2058746051 doi "https://doi.org/10.1016/0140-6736(92)91601-4" @default.
- W2058746051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1349676" @default.
- W2058746051 hasPublicationYear "1992" @default.
- W2058746051 type Work @default.
- W2058746051 sameAs 2058746051 @default.
- W2058746051 citedByCount "89" @default.
- W2058746051 countsByYear W20587460512012 @default.
- W2058746051 countsByYear W20587460512013 @default.
- W2058746051 countsByYear W20587460512014 @default.
- W2058746051 countsByYear W20587460512015 @default.
- W2058746051 countsByYear W20587460512016 @default.
- W2058746051 countsByYear W20587460512018 @default.
- W2058746051 countsByYear W20587460512019 @default.
- W2058746051 countsByYear W20587460512020 @default.
- W2058746051 crossrefType "journal-article" @default.
- W2058746051 hasAuthorship W2058746051A5027651090 @default.
- W2058746051 hasAuthorship W2058746051A5036974253 @default.
- W2058746051 hasAuthorship W2058746051A5040331916 @default.
- W2058746051 hasAuthorship W2058746051A5062382964 @default.
- W2058746051 hasAuthorship W2058746051A5076408981 @default.
- W2058746051 hasAuthorship W2058746051A5079336377 @default.
- W2058746051 hasAuthorship W2058746051A5081838665 @default.
- W2058746051 hasConcept C126322002 @default.
- W2058746051 hasConcept C197934379 @default.
- W2058746051 hasConcept C2775862500 @default.
- W2058746051 hasConcept C2778260677 @default.
- W2058746051 hasConcept C2778375690 @default.
- W2058746051 hasConcept C2779134260 @default.
- W2058746051 hasConcept C2779174533 @default.
- W2058746051 hasConcept C2780479503 @default.
- W2058746051 hasConcept C71924100 @default.
- W2058746051 hasConcept C90924648 @default.
- W2058746051 hasConceptScore W2058746051C126322002 @default.
- W2058746051 hasConceptScore W2058746051C197934379 @default.
- W2058746051 hasConceptScore W2058746051C2775862500 @default.
- W2058746051 hasConceptScore W2058746051C2778260677 @default.
- W2058746051 hasConceptScore W2058746051C2778375690 @default.
- W2058746051 hasConceptScore W2058746051C2779134260 @default.
- W2058746051 hasConceptScore W2058746051C2779174533 @default.
- W2058746051 hasConceptScore W2058746051C2780479503 @default.
- W2058746051 hasConceptScore W2058746051C71924100 @default.
- W2058746051 hasConceptScore W2058746051C90924648 @default.
- W2058746051 hasIssue "8804" @default.
- W2058746051 hasLocation W20587460511 @default.
- W2058746051 hasLocation W20587460512 @default.
- W2058746051 hasOpenAccess W2058746051 @default.
- W2058746051 hasPrimaryLocation W20587460511 @default.
- W2058746051 hasRelatedWork W2047076379 @default.
- W2058746051 hasRelatedWork W2078745520 @default.
- W2058746051 hasRelatedWork W2263605371 @default.
- W2058746051 hasRelatedWork W2352254143 @default.
- W2058746051 hasRelatedWork W2355129079 @default.
- W2058746051 hasRelatedWork W2382465907 @default.
- W2058746051 hasRelatedWork W2386497540 @default.
- W2058746051 hasRelatedWork W2407927805 @default.
- W2058746051 hasRelatedWork W2467986563 @default.
- W2058746051 hasRelatedWork W3032188930 @default.
- W2058746051 hasVolume "339" @default.
- W2058746051 isParatext "false" @default.
- W2058746051 isRetracted "false" @default.
- W2058746051 magId "2058746051" @default.
- W2058746051 workType "article" @default.