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• W2058746677 abstract "Abstract Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a treatment option for patients with hematopoietic malignancies that is hampered by treatment-related morbidity and mortality, in part the result of opportunistic infections, a direct consequence of delayed T-cell recovery. Thymic output can be improved by facilitation of thymic immigration, known to require precommitment of CD34+ cells. We demonstrate that Delta-like ligand-mediated predifferentiation of mobilized CD34+ cells in vitro results in a population of thymocyte-like cells arrested at a T/natural killer (NK)–cell progenitor stage. On intrahepatic transfer to Rag2−/−γc−/− mice, these cells selectively home to the thymus and differentiate toward surface T-cell receptor–αβ+ mature T cells considerably faster than animals transplanted with noncultured CD34+ cells. This finding creates the opportunity to develop an early T-cell reconstitution therapy to combine with HSCT." @default.
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• W2058746677 date "2010-01-14" @default.
• W2058746677 modified "2023-10-01" @default.
• W2058746677 title "In vitro–differentiated T/natural killer–cell progenitors derived from human CD34+ cells mature in the thymus" @default.
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• W2058746677 doi "https://doi.org/10.1182/blood-2009-05-223990" @default.
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