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- W2058749969 abstract "Puberty in the female rat is accompanied by a marked attenuation of the opioid inhibition of luteinizing hormone secretion. One factor which may contribute to this altered role is a change in the metabolism of opioid peptides during sexual maturation. β-Endorphin undergoes a considerable degree of metabolism through both C-terminal proteolysis and N-acetylation, and these metabolites do not possess opioid activity. The processing of β-endorphin in the hypothalamus and in the anterior and neurointermediate lobes of the pituitary gland in prepubertal and adult female rats was studied using gel filtration and high performance liquid chromatography coupled with radioimmunoassay. In the anterior lobe, high molecular weight precursors of β-endorphin (pro-opiomelanocortin and β-lipotropin) were present in prepubertal (28 days old) rats, but little authentic β-endorphin was detected. In contrast, only β-lipotropin and β-endorphin were present in mature (70 days old) animals. Only β-endorphin-sized peptides were present in the neurointermediate lobes of both prepubertal and adult rats. However, the proportion of N-acetylated metabolites was higher in sexually mature animals. In the hypothalamus, only β-endorphin-sized peptides were present in both juvenile and adult animals. However, C-terminal proteolysis increased with age (no acetylated metabolites were detectable in this tissue). The proportion of the total β-endorphin-like immunoreactivity attributable to β-endorphin was lower in young adult (first dioestrus after vaginal opening) (55%) and mature (dioestrus, 61–64 days old) rats (56%) compared to prepubertal (30 days old) animals (75%) and the proportions of non-acetylated metabolites [β-endorphin-(1–27) in young adults and β-endorphin-(1–26) in adults] were increased concomitantly. These changes were correlated with a reduced luteinizing hormone response to the opiate antagonist naloxone in adult compared to prepubertal rats. β-Endorphin is processed differently in the two lobes of the pituitary gland and in the hypothalamus and the degree of metabolism increases as the rat reaches sexual maturity. The increased metabolism of β-endorphin in the hypothalamus, the site most likely to be involved in the control of luteinizing hormone secretion, results in a reduction in the relative proportion of the opioid active parent peptide. Thus, increased inactivation of β-endorphin may contribute to the attenuation of the opioid inhibition of luteinizing hormone secretion observed during puberty." @default.
- W2058749969 created "2016-06-24" @default.
- W2058749969 creator A5043130821 @default.
- W2058749969 date "1985-11-01" @default.
- W2058749969 modified "2023-09-24" @default.
- W2058749969 title "Changes in the processing of β-endorphin in the hypothalamus and pituitary gland of female rats during sexual maturation" @default.
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- W2058749969 doi "https://doi.org/10.1016/0306-4522(85)90197-6" @default.