Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058759940> ?p ?o ?g. }
- W2058759940 endingPage "754" @default.
- W2058759940 startingPage "747" @default.
- W2058759940 abstract "Phase III efficacy trials of recombinant human immunodeficiency virus type 1 (HIV-1) envelope glycoproteins were postponed. In Phase I and II trials these candidate vaccines had failed to induce neutralizing antibodies against virus which had been isolated by co-culture with human peripheral blood mononuclear cells (PBMC). The aim of the present study was to determine assay conditions for detecting neutralization of primary HIV-1 isolates with sera from immunized individuals. We show that in two immunogenicity trials in rhesus macaques, recombinant HIV-1 SF2 gp120 induced antibodies which neutralized the primary HIV-1 SF13 isolate. Statistically significant in vitro neutralization required assays in which the incubation phase was extended. Sterile immunity was only seen with the highest level of neutralization, induced by a recombinant prime, peptide boost strategy. We recommend that neutralization assays with extended incubation phases should be used to monitor Phase III efficacy trials." @default.
- W2058759940 created "2016-06-24" @default.
- W2058759940 creator A5007062297 @default.
- W2058759940 creator A5013493031 @default.
- W2058759940 creator A5023133097 @default.
- W2058759940 creator A5048193217 @default.
- W2058759940 creator A5051660871 @default.
- W2058759940 creator A5055412954 @default.
- W2058759940 creator A5066613174 @default.
- W2058759940 creator A5074796369 @default.
- W2058759940 creator A5084792828 @default.
- W2058759940 creator A5091016491 @default.
- W2058759940 date "2004-01-01" @default.
- W2058759940 modified "2023-09-27" @default.
- W2058759940 title "Neutralization of primary HIV-1 SF13 can be detected in extended incubation phase assays with sera from monkeys immunized with recombinant HIV-1 SF2 gp120" @default.
- W2058759940 cites W1493944623 @default.
- W2058759940 cites W1528520360 @default.
- W2058759940 cites W1594804329 @default.
- W2058759940 cites W1968886334 @default.
- W2058759940 cites W1977243656 @default.
- W2058759940 cites W2031888235 @default.
- W2058759940 cites W2037345813 @default.
- W2058759940 cites W2037922132 @default.
- W2058759940 cites W2046448593 @default.
- W2058759940 cites W2060044395 @default.
- W2058759940 cites W2074895850 @default.
- W2058759940 cites W2077977437 @default.
- W2058759940 cites W2080173792 @default.
- W2058759940 cites W2084495395 @default.
- W2058759940 cites W2086130200 @default.
- W2058759940 cites W2105418223 @default.
- W2058759940 cites W2106014927 @default.
- W2058759940 cites W2109425369 @default.
- W2058759940 cites W2110287237 @default.
- W2058759940 cites W2127682720 @default.
- W2058759940 cites W2141813702 @default.
- W2058759940 cites W2144563230 @default.
- W2058759940 cites W2151835606 @default.
- W2058759940 cites W2156557297 @default.
- W2058759940 cites W2157210163 @default.
- W2058759940 cites W2175342233 @default.
- W2058759940 cites W2237082258 @default.
- W2058759940 cites W2256756668 @default.
- W2058759940 cites W2411447276 @default.
- W2058759940 cites W3217730596 @default.
- W2058759940 doi "https://doi.org/10.1016/j.vaccine.2003.08.031" @default.
- W2058759940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14741168" @default.
- W2058759940 hasPublicationYear "2004" @default.
- W2058759940 type Work @default.
- W2058759940 sameAs 2058759940 @default.
- W2058759940 citedByCount "6" @default.
- W2058759940 countsByYear W20587599402013 @default.
- W2058759940 crossrefType "journal-article" @default.
- W2058759940 hasAuthorship W2058759940A5007062297 @default.
- W2058759940 hasAuthorship W2058759940A5013493031 @default.
- W2058759940 hasAuthorship W2058759940A5023133097 @default.
- W2058759940 hasAuthorship W2058759940A5048193217 @default.
- W2058759940 hasAuthorship W2058759940A5051660871 @default.
- W2058759940 hasAuthorship W2058759940A5055412954 @default.
- W2058759940 hasAuthorship W2058759940A5066613174 @default.
- W2058759940 hasAuthorship W2058759940A5074796369 @default.
- W2058759940 hasAuthorship W2058759940A5084792828 @default.
- W2058759940 hasAuthorship W2058759940A5091016491 @default.
- W2058759940 hasConcept C104317684 @default.
- W2058759940 hasConcept C137061746 @default.
- W2058759940 hasConcept C14086860 @default.
- W2058759940 hasConcept C159047783 @default.
- W2058759940 hasConcept C159654299 @default.
- W2058759940 hasConcept C202751555 @default.
- W2058759940 hasConcept C203014093 @default.
- W2058759940 hasConcept C22070199 @default.
- W2058759940 hasConcept C2522874641 @default.
- W2058759940 hasConcept C2778190748 @default.
- W2058759940 hasConcept C2779261636 @default.
- W2058759940 hasConcept C2780195530 @default.
- W2058759940 hasConcept C2780727368 @default.
- W2058759940 hasConcept C2780868878 @default.
- W2058759940 hasConcept C2910359755 @default.
- W2058759940 hasConcept C40767141 @default.
- W2058759940 hasConcept C55493867 @default.
- W2058759940 hasConcept C86803240 @default.
- W2058759940 hasConceptScore W2058759940C104317684 @default.
- W2058759940 hasConceptScore W2058759940C137061746 @default.
- W2058759940 hasConceptScore W2058759940C14086860 @default.
- W2058759940 hasConceptScore W2058759940C159047783 @default.
- W2058759940 hasConceptScore W2058759940C159654299 @default.
- W2058759940 hasConceptScore W2058759940C202751555 @default.
- W2058759940 hasConceptScore W2058759940C203014093 @default.
- W2058759940 hasConceptScore W2058759940C22070199 @default.
- W2058759940 hasConceptScore W2058759940C2522874641 @default.
- W2058759940 hasConceptScore W2058759940C2778190748 @default.
- W2058759940 hasConceptScore W2058759940C2779261636 @default.
- W2058759940 hasConceptScore W2058759940C2780195530 @default.
- W2058759940 hasConceptScore W2058759940C2780727368 @default.
- W2058759940 hasConceptScore W2058759940C2780868878 @default.
- W2058759940 hasConceptScore W2058759940C2910359755 @default.
- W2058759940 hasConceptScore W2058759940C40767141 @default.
- W2058759940 hasConceptScore W2058759940C55493867 @default.