FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058765731> ?p ?o ?g. }

• W2058765731 endingPage "183" @default.
• W2058765731 startingPage "171" @default.
• W2058765731 abstract "A panel of 14 monoclonal antibodies with specificity for the O-antigenic polysaccharide chain of the lipopolysaccharide of the cell envelope of Salmonella typhimurium was established. The specificity of each antibody clone was determined against a set of Salmonella saccharide antigens, natural and synthetic, in passive hemagglutination and enzyme immunoassays. The monoclonal antibodies could be classified into at least five different groups: (i) O4 epitope specific, (ii) O4,12 specific, (iii) O4,122 specific, (iv) O5 specific, and (v) O12 specific. These specificities correspond to different structural and conformational domains of the polysaccharide chain, and often extend over more than one repeating unit (tetrasaccharide) of the polymer. The passive protection afforded by these antibodies was estimated in an experimental mouse typhoid model using S. typhimurium SH2201 for intraperitoneal challenge. Monoclonal antibodies of the IgG3 isotype were available for four of the epitope groups and were protective in the following order of activity O4 > O4, 12 ⩾ O4,122 ⪢ O12. The difference between O4 and O12 antibodies was >2500 fold in protective activity. Antibodies of the IgM class were highly protective irrespective of being of the O4,12 or O12 epitope specificity. Two IgA antibodies with O5 epitope specificity were not protective. The results show that both isotype and epitope specificity can be of importance for the protective ability of antibodies generated by the host." @default.
• W2058765731 created "2016-06-24" @default.
• W2058765731 creator A5010103437 @default.
• W2058765731 creator A5086648371 @default.
• W2058765731 creator A5089704603 @default.
• W2058765731 date "1987-03-01" @default.
• W2058765731 modified "2023-10-02" @default.
• W2058765731 title "Role of monoclonal O-antigen antibody epitope specificity and isotype in protection against experimental mouse typhoid" @default.
• W2058765731 cites W1511168027 @default.
• W2058765731 cites W1559760989 @default.
• W2058765731 cites W1565783012 @default.
• W2058765731 cites W1589286368 @default.
• W2058765731 cites W1590288489 @default.
• W2058765731 cites W1594382493 @default.
• W2058765731 cites W1639090197 @default.
• W2058765731 cites W1761816162 @default.
• W2058765731 cites W1874999943 @default.
• W2058765731 cites W1877482879 @default.
• W2058765731 cites W1974761606 @default.
• W2058765731 cites W1977007850 @default.
• W2058765731 cites W1989961245 @default.
• W2058765731 cites W1990615139 @default.
• W2058765731 cites W1996192007 @default.
• W2058765731 cites W1997537739 @default.
• W2058765731 cites W2004666722 @default.
• W2058765731 cites W2015077983 @default.
• W2058765731 cites W2015549544 @default.
• W2058765731 cites W2016749454 @default.
• W2058765731 cites W2030522563 @default.
• W2058765731 cites W2047541816 @default.
• W2058765731 cites W2047672334 @default.
• W2058765731 cites W2066861122 @default.
• W2058765731 cites W2068658385 @default.
• W2058765731 cites W2075138016 @default.
• W2058765731 cites W2087737282 @default.
• W2058765731 cites W2111826652 @default.
• W2058765731 cites W2114251811 @default.
• W2058765731 cites W2129773957 @default.
• W2058765731 cites W2142324754 @default.
• W2058765731 cites W2146955434 @default.
• W2058765731 cites W2149796286 @default.
• W2058765731 cites W2152972548 @default.
• W2058765731 cites W2160484205 @default.
• W2058765731 cites W2211441469 @default.
• W2058765731 cites W2280950842 @default.
• W2058765731 cites W2419310259 @default.
• W2058765731 doi "https://doi.org/10.1016/0882-4010(87)90019-2" @default.
• W2058765731 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2467161" @default.
• W2058765731 hasPublicationYear "1987" @default.
• W2058765731 type Work @default.
• W2058765731 sameAs 2058765731 @default.
• W2058765731 citedByCount "61" @default.
• W2058765731 countsByYear W20587657312012 @default.
• W2058765731 countsByYear W20587657312013 @default.
• W2058765731 countsByYear W20587657312014 @default.
• W2058765731 countsByYear W20587657312015 @default.
• W2058765731 countsByYear W20587657312016 @default.
• W2058765731 countsByYear W20587657312017 @default.
• W2058765731 countsByYear W20587657312018 @default.
• W2058765731 countsByYear W20587657312019 @default.
• W2058765731 countsByYear W20587657312020 @default.
• W2058765731 countsByYear W20587657312021 @default.
• W2058765731 countsByYear W20587657312022 @default.
• W2058765731 countsByYear W20587657312023 @default.
• W2058765731 crossrefType "journal-article" @default.
• W2058765731 hasAuthorship W2058765731A5010103437 @default.
• W2058765731 hasAuthorship W2058765731A5086648371 @default.
• W2058765731 hasAuthorship W2058765731A5089704603 @default.
• W2058765731 hasConcept C147483822 @default.
• W2058765731 hasConcept C153911025 @default.
• W2058765731 hasConcept C159047783 @default.
• W2058765731 hasConcept C159654299 @default.
• W2058765731 hasConcept C195616568 @default.
• W2058765731 hasConcept C203014093 @default.
• W2058765731 hasConcept C2777991845 @default.
• W2058765731 hasConcept C542903549 @default.
• W2058765731 hasConcept C86803240 @default.
• W2058765731 hasConceptScore W2058765731C147483822 @default.
• W2058765731 hasConceptScore W2058765731C153911025 @default.
• W2058765731 hasConceptScore W2058765731C159047783 @default.
• W2058765731 hasConceptScore W2058765731C159654299 @default.
• W2058765731 hasConceptScore W2058765731C195616568 @default.
• W2058765731 hasConceptScore W2058765731C203014093 @default.
• W2058765731 hasConceptScore W2058765731C2777991845 @default.
• W2058765731 hasConceptScore W2058765731C542903549 @default.
• W2058765731 hasConceptScore W2058765731C86803240 @default.
• W2058765731 hasIssue "3" @default.
• W2058765731 hasLocation W20587657311 @default.
• W2058765731 hasLocation W20587657312 @default.
• W2058765731 hasOpenAccess W2058765731 @default.
• W2058765731 hasPrimaryLocation W20587657311 @default.
• W2058765731 hasRelatedWork W1604248381 @default.
• W2058765731 hasRelatedWork W1975565982 @default.
• W2058765731 hasRelatedWork W1989765228 @default.
• W2058765731 hasRelatedWork W2001280522 @default.
• W2058765731 hasRelatedWork W2051909045 @default.
• W2058765731 hasRelatedWork W2065045920 @default.
• W2058765731 hasRelatedWork W2101049085 @default.

• next