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• W2058769013 abstract "Perfusate obtained from the intra-articular space of the knee (100 μl/min) in the halothane-anesthetized cat under resting conditions shows no detectable substance P-like immunoreactivity (SP-LI: <2pg/20min). Antidromic activation by electrical stimulation of the sciatic nerve at stimulus intensities which evoke activity in Aβ/Aδ/C but not Aβ fibers or the local administration of capsaicin (10−4 M) into the intra-articular perfusate results in a stimulus-dependent increase in the levels of SP-LI in the perfusate. This release is diminished in a naloxone- (1 mg/kg, i.v.) reversible fashion by sufentanil, d-Ala2-d-Leu5-enkephalin, and d-Pen2-d-Pen5- enkephalin, but not by U50488H (10−4 M) added to the intra-articular perfusate. These observations thus suggest that the peripheral stores of SP-LI in small primary afferents are subject to release by antidromic activity and this release is subject to modulation by μ/Δ receptors on these peripheral terminals." @default.
• W2058769013 created "2016-06-24" @default.
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• W2058769013 date "1988-08-01" @default.
• W2058769013 modified "2023-10-12" @default.
• W2058769013 title "Substance P release from knee joint afferent terminals: modulation by opioids" @default.
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• W2058769013 doi "https://doi.org/10.1016/0006-8993(88)90474-x" @default.
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