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- W2058774002 abstract "Abstract Aiming at understanding of the gene networks in animal development and reconstructing development in silico, we have performed expression and functional analysis of the 100-Mb genome of the nematode Caenorhabditis elegans . Some 19,000 genes were predicted from the genome sequence and we identified more than 10,000 cDNA species through our EST project. We have analyzed their expression patterns systematically by using of our whole mount in situ hybridization method. Thus far, hybridization with some 9000 genes was done, and the annotations of the expression patterns (spatial and temporal) were provided. Based on the annotation of about 7000 genes, we tried the clustering analysis of the expression patterns. Function analysis of the clustered genes was also performed by using of RNA-mediated interference (RNAi) and 4D microscope, leading to functional classification of the genes during the very early embryogenesis. The expression analysis also revealed a gene network for translational regulation of maternal mRNAs." @default.
- W2058774002 created "2016-06-24" @default.
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- W2058774002 date "2002-12-01" @default.
- W2058774002 modified "2023-09-27" @default.
- W2058774002 title "Genomic approaches to early development of C. elegans" @default.
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- W2058774002 doi "https://doi.org/10.1016/s0531-5131(02)01145-7" @default.
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