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- W2058775711 abstract "Abstract The metabolism of 3H-α-ecdysone has been investigated in larvae of Tenebrio molitor within a moulting cycle. The metabolization occurs by hydroxylation, dehydration, and conjugation. A total of 8 metabolites including α- and β-ecdysone were found. Peak I was cleaved enzymatically up to 56%. The hydrolized part consists of esters of sulfuric- and glucuronic acid with compounds II and III, also with α-ecdysone and 3-dehydroecdysterone to a lesser degree. The hydroxylation of α-ecdysone to β-ecdysone is a very rapid one. Velocity and intensity depends on the physiological stage of the larvae. On days with a large endogenous hormone titer they are maximal and on days with a low endogenous titer they are lower. The rate of conversion of α- to β-ecdysone shows a correlation with the endogenous titer and vice versa. At a low endogenous titer the rate of excretion is very strong, in larvae aged to 2 to 5 days and also 7 to 8 days, 8 h after injection 50 to 80% of injected activity was recovered in the faeces. At the beginning of the moulting cycle 3% and at the 6th day 30% (hormone titer maximum) of activity is excreted. The unexpected high rate of excretion at the first day is compensated by increasing metabolism and storage. The faeces mainly consist of conjugates and α- and β-ecdysone. A correlation between the appearance of these compounds and the physiological stage of the larvae could be found. On those days with low endogenous titer the quota of ecdysone (α and β) is higher." @default.
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- W2058775711 date "1977-01-01" @default.
- W2058775711 modified "2023-10-02" @default.
- W2058775711 title "Der metabolismus von 3H-α-ecdyson bei larven von Tenebrio molitor" @default.
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- W2058775711 doi "https://doi.org/10.1016/0022-1910(77)90057-9" @default.
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