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• W2058778918 abstract "The Son of Sevenless (Sos) proteins control receptor-mediated activation of Ras by catalyzing the exchange of guanosine diphosphate for guanosine triphosphate on Ras. The NH2-terminal region of Sos contains a Dbl homology (DH) domain in tandem with a pleckstrin homology (PH) domain. In COS-1 cells, the DH domain of Sos stimulated guanine nucleotide exchange on Rac but not Cdc42 in vitro and in vivo. The tandem DH-PH domain of Sos (DH-PH-Sos) was defective in Rac activation but regained Rac stimulating activity when it was coexpressed with activated Ras. Ras-mediated activation of DH-PH-Sos did not require activation of mitogen-activated protein kinase but it was dependent on activation of phosphoinositide 3-kinase. These results reveal a potential mechanism for coupling of Ras and Rac signaling pathways." @default.
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• W2058778918 date "1998-01-23" @default.
• W2058778918 modified "2023-10-17" @default.
• W2058778918 title "Coupling of Ras and Rac Guanosine Triphosphatases Through the Ras Exchanger Sos" @default.
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• W2058778918 doi "https://doi.org/10.1126/science.279.5350.560" @default.
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