Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058787922> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2058787922 endingPage "743" @default.
- W2058787922 startingPage "737" @default.
- W2058787922 abstract "Activated platelets release potent vasoactive factors. Previous studies have focused on mechanisms by which vascular abnormalities lead to altered responses of atherosclerotic arteries. We tested the hypothesis that the activation of platelets from hypercholesterolemic humans produces abnormal vascular responses. Responses to intraluminal and abluminal activation of platelets from normal subjects and type II hypercholesterolemic patients (total cholesterol, 274 +/- 16 [mean +/- SEM] mg/dl) were examined in carotid arteries from normal rabbits perfused in vitro. Intraluminal activation of normal platelets produced pronounced dilatation of arteries preconstricted with phenylephrine. Vasodilator responses to intraluminal activation of platelets from hypercholesterolemic patients were greatly impaired. Vasodilator responses to platelets from hypercholesterolemic patients were not restored to normal by LY53,857 (10(-5) M), a 5-hydroxytryptamine2-serotonergic antagonist, by SQ29,548 (10(-5) M), a thromboxane A2/prostaglandin H2 receptor antagonist, or by apyrase (1.5 units/ml), an enzyme with ADPase activity. Abluminal activation of normal platelets produced modest constriction in quiescent arteries, and abluminal activation of platelets from hypercholesterolemic patients produced augmented vasoconstrictor responses. The major finding is that vasodilator responses to platelets from hypercholesterolemic patients are profoundly impaired, and vasoconstrictor responses to platelets from hypercholesterolemic patients are augmented. Mechanisms in addition to increased release of serotonin, thromboxane, and ADP appear to contribute to impaired vasodilator responses to hypercholesterolemic platelets. Thus, alteration of platelets by hypercholesterolemia, as well as altered vascular reactivity, may contribute to abnormal vascular responses in atherosclerosis." @default.
- W2058787922 created "2016-06-24" @default.
- W2058787922 creator A5008803210 @default.
- W2058787922 creator A5031087237 @default.
- W2058787922 creator A5047536789 @default.
- W2058787922 creator A5077989922 @default.
- W2058787922 creator A5082988598 @default.
- W2058787922 date "1993-04-01" @default.
- W2058787922 modified "2023-10-06" @default.
- W2058787922 title "Altered vascular responses to platelets from hypercholesterolemic humans." @default.
- W2058787922 cites W1566166165 @default.
- W2058787922 cites W1965526093 @default.
- W2058787922 cites W1975867565 @default.
- W2058787922 cites W1982291889 @default.
- W2058787922 cites W2003432589 @default.
- W2058787922 cites W2005516729 @default.
- W2058787922 cites W2010581714 @default.
- W2058787922 cites W2012214760 @default.
- W2058787922 cites W2016412414 @default.
- W2058787922 cites W2022955698 @default.
- W2058787922 cites W2030279976 @default.
- W2058787922 cites W2043840414 @default.
- W2058787922 cites W2046014987 @default.
- W2058787922 cites W2057232608 @default.
- W2058787922 cites W2058129309 @default.
- W2058787922 cites W2070635537 @default.
- W2058787922 cites W2074358213 @default.
- W2058787922 cites W2075986959 @default.
- W2058787922 cites W2083980830 @default.
- W2058787922 cites W2093518775 @default.
- W2058787922 cites W2163076142 @default.
- W2058787922 cites W2318504971 @default.
- W2058787922 cites W2319045997 @default.
- W2058787922 cites W2614133439 @default.
- W2058787922 cites W4211054454 @default.
- W2058787922 cites W4241878308 @default.
- W2058787922 cites W4299347395 @default.
- W2058787922 doi "https://doi.org/10.1161/01.res.72.4.737" @default.
- W2058787922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8443865" @default.
- W2058787922 hasPublicationYear "1993" @default.
- W2058787922 type Work @default.
- W2058787922 sameAs 2058787922 @default.
- W2058787922 citedByCount "28" @default.
- W2058787922 countsByYear W20587879222012 @default.
- W2058787922 countsByYear W20587879222013 @default.
- W2058787922 countsByYear W20587879222014 @default.
- W2058787922 countsByYear W20587879222017 @default.
- W2058787922 countsByYear W20587879222020 @default.
- W2058787922 countsByYear W20587879222022 @default.
- W2058787922 crossrefType "journal-article" @default.
- W2058787922 hasAuthorship W2058787922A5008803210 @default.
- W2058787922 hasAuthorship W2058787922A5031087237 @default.
- W2058787922 hasAuthorship W2058787922A5047536789 @default.
- W2058787922 hasAuthorship W2058787922A5077989922 @default.
- W2058787922 hasAuthorship W2058787922A5082988598 @default.
- W2058787922 hasBestOaLocation W20587879221 @default.
- W2058787922 hasConcept C120770815 @default.
- W2058787922 hasConcept C126322002 @default.
- W2058787922 hasConcept C134018914 @default.
- W2058787922 hasConcept C2776785769 @default.
- W2058787922 hasConcept C2779508331 @default.
- W2058787922 hasConcept C2779961880 @default.
- W2058787922 hasConcept C2781024287 @default.
- W2058787922 hasConcept C2908519926 @default.
- W2058787922 hasConcept C3018697912 @default.
- W2058787922 hasConcept C71924100 @default.
- W2058787922 hasConcept C89560881 @default.
- W2058787922 hasConceptScore W2058787922C120770815 @default.
- W2058787922 hasConceptScore W2058787922C126322002 @default.
- W2058787922 hasConceptScore W2058787922C134018914 @default.
- W2058787922 hasConceptScore W2058787922C2776785769 @default.
- W2058787922 hasConceptScore W2058787922C2779508331 @default.
- W2058787922 hasConceptScore W2058787922C2779961880 @default.
- W2058787922 hasConceptScore W2058787922C2781024287 @default.
- W2058787922 hasConceptScore W2058787922C2908519926 @default.
- W2058787922 hasConceptScore W2058787922C3018697912 @default.
- W2058787922 hasConceptScore W2058787922C71924100 @default.
- W2058787922 hasConceptScore W2058787922C89560881 @default.
- W2058787922 hasIssue "4" @default.
- W2058787922 hasLocation W20587879221 @default.
- W2058787922 hasLocation W20587879222 @default.
- W2058787922 hasOpenAccess W2058787922 @default.
- W2058787922 hasPrimaryLocation W20587879221 @default.
- W2058787922 hasRelatedWork W14888083 @default.
- W2058787922 hasRelatedWork W2058787922 @default.
- W2058787922 hasRelatedWork W2067001088 @default.
- W2058787922 hasRelatedWork W2095739958 @default.
- W2058787922 hasRelatedWork W2119869612 @default.
- W2058787922 hasRelatedWork W2131058877 @default.
- W2058787922 hasRelatedWork W2407664714 @default.
- W2058787922 hasRelatedWork W2409474136 @default.
- W2058787922 hasRelatedWork W2980115092 @default.
- W2058787922 hasRelatedWork W3148878922 @default.
- W2058787922 hasVolume "72" @default.
- W2058787922 isParatext "false" @default.
- W2058787922 isRetracted "false" @default.
- W2058787922 magId "2058787922" @default.
- W2058787922 workType "article" @default.