FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058799785> ?p ?o ?g. }

• W2058799785 endingPage "5295" @default.
• W2058799785 startingPage "5290" @default.
• W2058799785 abstract "Ferritins are ubiquitous proteins that concentrate, store, and detoxify intracellular iron through oxidation of Fe2+ (ferroxidation), followed by translocation and hydrolysis to form a large inorganic mineral core. A series of mutagenesis, kinetics, and spectroscopic studies of ferritin led to the proposal that the oxidation/translocation path involves a diiron protein site. Recent stopped-flow absorption and rapid freeze−quench Mössbauer studies have identified a single peroxodiferric species as the initial transient intermediate formed in recombinant frog M ferritin during rapid ferroxidation [Pereira, S. A., Small, W., Krebs, C., Tavares, P., Edmondson, D. E., Theil, E. C., and Huynh, B. H. (1998) Biochemistry 37, 9871−9876]. To further characterize this transient intermediate and to establish unambiguously the peroxodiferric assignment, rapid freeze−quenching was used to trap the initial intermediate for resonance Raman investigation. Discrete vibrational modes are observed for this intermediate, indicating a single chromophore in a homogeneous state, in agreement with the Mössbauer conclusions. The frequency at 851 cm-1 is assigned as ν(O−O) of the bound peroxide, and the pair of frequencies at 485 and 499 cm-1 is attributed, respectively, to νs and νas of Fe−O2−Fe. Identification of the chromophore as a μ-1,2 bridged diferric peroxide is provided by the isotope sensitivity of these Raman bands. Similar peroxodiferric intermediates have been detected in a mutant of the R2 subunit of ribonucleotide reductase from Escherichia coli and chemically reduced Δ9 stearoyl-acyl carrier protein desaturase (Δ9D), but in contrast, the ferritin intermediate is trapped from the true reaction pathway of the native protein. Differences in the Raman signatures of these peroxide species are assigned to variations in Fe−O−O−Fe angles and may relate to whether the iron is retained in the catalytic center or released as an oxidized product." @default.
• W2058799785 created "2016-06-24" @default.
• W2058799785 creator A5006813426 @default.
• W2058799785 creator A5009559356 @default.
• W2058799785 creator A5042128054 @default.
• W2058799785 creator A5050467129 @default.
• W2058799785 creator A5068242761 @default.
• W2058799785 creator A5077146148 @default.
• W2058799785 creator A5079246484 @default.
• W2058799785 date "1999-04-01" @default.
• W2058799785 modified "2023-10-03" @default.
• W2058799785 title "The Ferroxidase Reaction of Ferritin Reveals a Diferric μ-1,2 Bridging Peroxide Intermediate in Common with Other O₂-Activating Non-Heme Diiron Proteins" @default.
• W2058799785 cites W138169624 @default.
• W2058799785 cites W1974701938 @default.
• W2058799785 cites W1975197163 @default.
• W2058799785 cites W1981704948 @default.
• W2058799785 cites W1983845336 @default.
• W2058799785 cites W1993284652 @default.
• W2058799785 cites W2002276655 @default.
• W2058799785 cites W2002843987 @default.
• W2058799785 cites W2013420550 @default.
• W2058799785 cites W2018063951 @default.
• W2058799785 cites W2025574960 @default.
• W2058799785 cites W2033853711 @default.
• W2058799785 cites W2047609835 @default.
• W2058799785 cites W2059219903 @default.
• W2058799785 cites W2060621094 @default.
• W2058799785 cites W2069044991 @default.
• W2058799785 cites W2091302502 @default.
• W2058799785 cites W2094879559 @default.
• W2058799785 doi "https://doi.org/10.1021/bi990095l" @default.
• W2058799785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10220314" @default.
• W2058799785 hasPublicationYear "1999" @default.
• W2058799785 type Work @default.
• W2058799785 sameAs 2058799785 @default.
• W2058799785 citedByCount "138" @default.
• W2058799785 countsByYear W20587997852012 @default.
• W2058799785 countsByYear W20587997852013 @default.
• W2058799785 countsByYear W20587997852014 @default.
• W2058799785 countsByYear W20587997852015 @default.
• W2058799785 countsByYear W20587997852016 @default.
• W2058799785 countsByYear W20587997852017 @default.
• W2058799785 countsByYear W20587997852018 @default.
• W2058799785 countsByYear W20587997852019 @default.
• W2058799785 countsByYear W20587997852020 @default.
• W2058799785 countsByYear W20587997852021 @default.
• W2058799785 countsByYear W20587997852022 @default.
• W2058799785 crossrefType "journal-article" @default.
• W2058799785 hasAuthorship W2058799785A5006813426 @default.
• W2058799785 hasAuthorship W2058799785A5009559356 @default.
• W2058799785 hasAuthorship W2058799785A5042128054 @default.
• W2058799785 hasAuthorship W2058799785A5050467129 @default.
• W2058799785 hasAuthorship W2058799785A5068242761 @default.
• W2058799785 hasAuthorship W2058799785A5077146148 @default.
• W2058799785 hasAuthorship W2058799785A5079246484 @default.
• W2058799785 hasConcept C105768512 @default.
• W2058799785 hasConcept C120665830 @default.
• W2058799785 hasConcept C121332964 @default.
• W2058799785 hasConcept C148898269 @default.
• W2058799785 hasConcept C161790260 @default.
• W2058799785 hasConcept C178790620 @default.
• W2058799785 hasConcept C181199279 @default.
• W2058799785 hasConcept C185592680 @default.
• W2058799785 hasConcept C192468462 @default.
• W2058799785 hasConcept C2776217839 @default.
• W2058799785 hasConcept C2778319317 @default.
• W2058799785 hasConcept C2781048764 @default.
• W2058799785 hasConcept C40003534 @default.
• W2058799785 hasConcept C55493867 @default.
• W2058799785 hasConcept C62520636 @default.
• W2058799785 hasConcept C71240020 @default.
• W2058799785 hasConcept C75473681 @default.
• W2058799785 hasConcept C8010536 @default.
• W2058799785 hasConceptScore W2058799785C105768512 @default.
• W2058799785 hasConceptScore W2058799785C120665830 @default.
• W2058799785 hasConceptScore W2058799785C121332964 @default.
• W2058799785 hasConceptScore W2058799785C148898269 @default.
• W2058799785 hasConceptScore W2058799785C161790260 @default.
• W2058799785 hasConceptScore W2058799785C178790620 @default.
• W2058799785 hasConceptScore W2058799785C181199279 @default.
• W2058799785 hasConceptScore W2058799785C185592680 @default.
• W2058799785 hasConceptScore W2058799785C192468462 @default.
• W2058799785 hasConceptScore W2058799785C2776217839 @default.
• W2058799785 hasConceptScore W2058799785C2778319317 @default.
• W2058799785 hasConceptScore W2058799785C2781048764 @default.
• W2058799785 hasConceptScore W2058799785C40003534 @default.
• W2058799785 hasConceptScore W2058799785C55493867 @default.
• W2058799785 hasConceptScore W2058799785C62520636 @default.
• W2058799785 hasConceptScore W2058799785C71240020 @default.
• W2058799785 hasConceptScore W2058799785C75473681 @default.
• W2058799785 hasConceptScore W2058799785C8010536 @default.
• W2058799785 hasIssue "17" @default.
• W2058799785 hasLocation W20587997851 @default.
• W2058799785 hasLocation W20587997852 @default.
• W2058799785 hasOpenAccess W2058799785 @default.
• W2058799785 hasPrimaryLocation W20587997851 @default.
• W2058799785 hasRelatedWork W1993884933 @default.
• W2058799785 hasRelatedWork W2009092088 @default.

• next