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- W2058810129 abstract "SNARE [soluble N-ethylmaleimide-sensitive factor (NSF) attachment protein (SNAP) receptor] proteins control the membrane-fusion events of eukaryotic membrane-trafficking pathways. Specific vesicular and target SNAREs operate in specific trafficking routes, but the degree of specificity of SNARE functions is still elusive. Apical fusion requires the polarized distribution at the apical surface of the t-SNARE syntaxin 3, and several v-SNAREs including TI-VAMP and VAMP8 operate at the apical plasma membrane in polarized epithelial cells. It is not known, however, whether specific v-SNAREs are involved in direct and indirect routes to the apical surface. Here, we used RNAi to assess the role of two tetanus-neurotoxin-insensitive v-SNAREs, TI-VAMP/VAMP7 and VAMP8, in the sorting of raft- and non-raft-associated apical markers that follow either a direct or a transcytotic delivery, respectively, in FRT or Caco2 cells. We show that TI-VAMP mediates the direct apical delivery of both raft- and non-raft-associated proteins. By contrast, sorting by means of the transcytotic pathway is not affected by TI-VAMP knockdown but does appear to be regulated by VAMP8. Together with the specific role of VAMP3 in basolateral transport, our results demonstrate a high degree of specificity in v-SNARE function in polarized cells." @default.
- W2058810129 created "2016-06-24" @default.
- W2058810129 creator A5001082512 @default.
- W2058810129 creator A5014672059 @default.
- W2058810129 creator A5021877231 @default.
- W2058810129 creator A5053283412 @default.
- W2058810129 date "2007-09-15" @default.
- W2058810129 modified "2023-10-15" @default.
- W2058810129 title "Distinct v-SNAREs regulate direct and indirect apical delivery in polarized epithelial cells" @default.
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- W2058810129 doi "https://doi.org/10.1242/jcs.007948" @default.
- W2058810129 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17878240" @default.
- W2058810129 hasPublicationYear "2007" @default.
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