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- W2058821306 abstract "Xeroderma pigmentosum complementation group E binding factor (XPE-BF) is a damaged DNA binding protein that is deficient in a subset of patients from complememtation group E of xeroderma pigmentosum. The protein recognizes various forms of DNA damage including some cyclobutane pyrimidine dimers, 6-4 photoproducts, cis-diamminedichloroplatinum(II) adducts, and single-stranded DNA. We now show that is also recognizes damage induced by nitrogen mustard, N-methyl-N′-nitro-N-nitrosoguanidine, and depurination, but has no detectable affinity for DNA adducts generated by trans-diamminedichloroplatinum(II), 4-nitroquinoline-N-oxide, 8-methoxypsoralen, or enzymatically methylated cytosine and adenine. The failure to recognize 4-nitroquinoline-N-oxide and 8-methoxypsoralen adducts is consistent with previous reports that XPE cells carry out wild-type levels of repair synthesis after DNA damage by those drugs. These results demonstrate that XPE-BF is a versatile damage recognition protein, but suggest that other proteins must contribute to the recognition of DNA lesions for the human excision repair pathway." @default.
- W2058821306 created "2016-06-24" @default.
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- W2058821306 date "1994-10-01" @default.
- W2058821306 modified "2023-10-18" @default.
- W2058821306 title "Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage" @default.
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- W2058821306 doi "https://doi.org/10.1016/0027-5107(94)90012-4" @default.
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