FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2058832208> ?p ?o ?g. }

• W2058832208 endingPage "382" @default.
• W2058832208 startingPage "376" @default.
• W2058832208 abstract "In the present study, we analyzed the mechanism by which human Langerhans cells (LC), the dendritic cells (DC) from epidermis, support the induction of a primary allogeneic T cell response. We reported that paraformaldehyde (PF) fixation completely abrogated the stimulatory property of freshly isolated LC, although the level of major histocompatibility complex (MHC) class II antigen (Ag) expression was unaltered by the fixative. Addition of either interleukin (IL)-1 beta and/or IL-6, during the mixed epidermal cell lymphocyte reaction, failed to restore the proliferative response. By contrast, when human LC were incubated for 3 days in culture medium before fixation, they retained a low but significant allostimulatory capacity. Trypsin treatment of incubated LC before fixation did not impair their function, suggesting that stimulatory activity by fixed incubated LC did not merely reflect a repair of LC membrane after trypsin trauma suffered during epidermal cell (EC) isolation. More interestingly, we found that addition of interferon-gamma during LC incubation mediated an enhanced allostimulatory activity by the PF-fixed LC. Acquisition of allostimulatory property by in vitro activated and fixed LC did not correlate with increased MHC class II Ag expression at the cell surface. By contrast, we showed that ICAM-1 Ag expression by human LC is involved in this maturation process. Finally, we found that once human LC have been activated, IL-1 beta, but not IL-6, could serve as a costimulatory factor in the primary allogeneic T cell response. In conclusion, the data suggest that human LC accessory function is not constitutive but requires an activation step which can be provided by interferon-gamma during LC-T cell interaction." @default.
• W2058832208 created "2016-06-24" @default.
• W2058832208 creator A5024343613 @default.
• W2058832208 creator A5053154374 @default.
• W2058832208 creator A5081841730 @default.
• W2058832208 creator A5087397688 @default.
• W2058832208 date "1993-02-01" @default.
• W2058832208 modified "2023-09-27" @default.
• W2058832208 title "Dissection of human Langerhans cells' allostimulatory function: The need for an activation step for full development of accessory function" @default.
• W2058832208 cites W1526039364 @default.
• W2058832208 cites W1965742429 @default.
• W2058832208 cites W1966408842 @default.
• W2058832208 cites W1974879161 @default.
• W2058832208 cites W1983427343 @default.
• W2058832208 cites W1987616397 @default.
• W2058832208 cites W1990209233 @default.
• W2058832208 cites W1992380147 @default.
• W2058832208 cites W1997317519 @default.
• W2058832208 cites W1997621463 @default.
• W2058832208 cites W2000459644 @default.
• W2058832208 cites W2000581651 @default.
• W2058832208 cites W2009419456 @default.
• W2058832208 cites W2009690601 @default.
• W2058832208 cites W2009914165 @default.
• W2058832208 cites W2010350911 @default.
• W2058832208 cites W2011932087 @default.
• W2058832208 cites W2021685948 @default.
• W2058832208 cites W2024299618 @default.
• W2058832208 cites W2024325269 @default.
• W2058832208 cites W2028466126 @default.
• W2058832208 cites W2033164429 @default.
• W2058832208 cites W2035919366 @default.
• W2058832208 cites W2045219244 @default.
• W2058832208 cites W2088689097 @default.
• W2058832208 cites W2090169073 @default.
• W2058832208 cites W2091329667 @default.
• W2058832208 cites W2096152012 @default.
• W2058832208 cites W2114639640 @default.
• W2058832208 cites W2125504851 @default.
• W2058832208 cites W2135272173 @default.
• W2058832208 cites W2148647317 @default.
• W2058832208 cites W2174557896 @default.
• W2058832208 cites W2177327503 @default.
• W2058832208 doi "https://doi.org/10.1002/eji.1830230212" @default.
• W2058832208 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8436173" @default.
• W2058832208 hasPublicationYear "1993" @default.
• W2058832208 type Work @default.
• W2058832208 sameAs 2058832208 @default.
• W2058832208 citedByCount "36" @default.
• W2058832208 crossrefType "journal-article" @default.
• W2058832208 hasAuthorship W2058832208A5024343613 @default.
• W2058832208 hasAuthorship W2058832208A5053154374 @default.
• W2058832208 hasAuthorship W2058832208A5081841730 @default.
• W2058832208 hasAuthorship W2058832208A5087397688 @default.
• W2058832208 hasConcept C147483822 @default.
• W2058832208 hasConcept C153911025 @default.
• W2058832208 hasConcept C203014093 @default.
• W2058832208 hasConcept C207936829 @default.
• W2058832208 hasConcept C2776090121 @default.
• W2058832208 hasConcept C2778814158 @default.
• W2058832208 hasConcept C86803240 @default.
• W2058832208 hasConcept C8891405 @default.
• W2058832208 hasConcept C95444343 @default.
• W2058832208 hasConceptScore W2058832208C147483822 @default.
• W2058832208 hasConceptScore W2058832208C153911025 @default.
• W2058832208 hasConceptScore W2058832208C203014093 @default.
• W2058832208 hasConceptScore W2058832208C207936829 @default.
• W2058832208 hasConceptScore W2058832208C2776090121 @default.
• W2058832208 hasConceptScore W2058832208C2778814158 @default.
• W2058832208 hasConceptScore W2058832208C86803240 @default.
• W2058832208 hasConceptScore W2058832208C8891405 @default.
• W2058832208 hasConceptScore W2058832208C95444343 @default.
• W2058832208 hasIssue "2" @default.
• W2058832208 hasLocation W20588322081 @default.
• W2058832208 hasLocation W20588322082 @default.
• W2058832208 hasOpenAccess W2058832208 @default.
• W2058832208 hasPrimaryLocation W20588322081 @default.
• W2058832208 hasRelatedWork W1970251634 @default.
• W2058832208 hasRelatedWork W1986527938 @default.
• W2058832208 hasRelatedWork W1999436383 @default.
• W2058832208 hasRelatedWork W2000941383 @default.
• W2058832208 hasRelatedWork W2020795276 @default.
• W2058832208 hasRelatedWork W2031508422 @default.
• W2058832208 hasRelatedWork W2044843571 @default.
• W2058832208 hasRelatedWork W2105363227 @default.
• W2058832208 hasRelatedWork W2490929826 @default.
• W2058832208 hasRelatedWork W4213245119 @default.
• W2058832208 hasVolume "23" @default.
• W2058832208 isParatext "false" @default.
• W2058832208 isRetracted "false" @default.
• W2058832208 magId "2058832208" @default.
• W2058832208 workType "article" @default.